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    1. Cell Cycle/DNA Damage
    2. Topoisomerase

    LMP744 hydrochloride (Synonyms: MJ-III65 hydrochloride; NSC706744 hydrochloride)

    目录号: HY-U00248A
    产品使用指南

    LMP744 hydrochloride (MJ-III65 hydrochloride) 是一种 DNA 嵌和剂,是 拓扑异构酶 1 (Top1) 抑制剂,具有抗肿瘤活性。

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    LMP744 hydrochloride Chemical Structure

    LMP744 hydrochloride Chemical Structure

    CAS No. : 308246-57-3

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    1 mg ¥14400 Get quote
    5 mg ¥32400 Get quote
    10 mg ¥55100 Get quote
    20 mg ¥97200 Get quote

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    Other Forms of LMP744 hydrochloride:

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    • 参考文献

    Description

    LMP744 hydrochloride (MJ-III65 hydrochloride) is a DNA intercalator and Topoisomerase (Top1) inhibitor with antitumor activity[1].

    IC50 & Target

    Top1[1].

    In Vitro

    The GI50 value of LMP744 (MJ-III-65) for NCI60 cells is 0.1 μM[1].
    LMP744 (0.1-5 μM, 3 days) induces dose-dependent accumulation of cells in the S and G2 phases of the cell cycle[1].

    Cell Cytotoxicity Assay[1]

    Cell Line: P388 and P388 Top1-deficient murine leukemia cells
    Concentration: 0.1-100 μM
    Incubation Time: 3 days
    Result: induced dose-dependent accumulation of cells in the S and G2 phases of the cell cycle
    In Vivo

    MJ-III-65 (10-50 mg/kg) administered i.v. push once a week for 4 weeks in nude mice moderately actives against human A253 and FaDu tumor xenografts without significant toxicity[2].

    Animal Model: Athymic nude mice (nu/nu, female, 20-25 g, 8-12 weeks old) transplanted with A253 and FaDu human head and neck xenografts[2].
    Dosage: 10, 25, or 50 mg/kg/week, 4 weeks
    Administration: i.v. push via tail vein
    Result: moderately actived against human A253 and FaDu tumor xenografts without significant toxicity
    Solvent & Solubility
    In Vitro: 

    10 mM in DMSO

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.0453 mL 10.2266 mL 20.4532 mL
    5 mM 0.4091 mL 2.0453 mL 4.0906 mL
    10 mM 0.2045 mL 1.0227 mL 2.0453 mL
    *Please refer to the solubility information to select the appropriate solvent.
    References
    Molecular Weight

    488.92

    Formula

    C??H??ClN?O?

    CAS No.

    308246-57-3

    SMILES

    OCCNCCCN1C2=C(C(C3=CC(OCO4)=C4C=C23)=O)C5=CC(OC)=C(OC)C=C5C1=O.Cl

    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.

    Shipping

    Room temperature in continental US; may vary elsewhere

    • 摩尔计算器

    • 稀释计算器

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass   Concentration   Volume   Molecular Weight *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2

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    产品名称:
    LMP744 hydrochloride
    目录号:
    HY-U00248A
    需求量:

    LMP744 hydrochloride

    Cat. No.: HY-U00248A

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