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    1. Membrane Transporter/Ion Channel
    2. Sodium Channel

    Nav1.7-IN-3 

    目录号: HY-101789
    产品使用指南

    Nav1.7-IN-3是选择性,有口服活性的电压门控钠离子通道 Nav1.7 抑制剂,IC50 为8 nM。CNS渗透能力有限。缓解疼痛。

    MCE 的所有产品仅用作科学研究,我们不为任何个人用途提供产品和服务

    Nav1.7-IN-3 Chemical Structure

    Nav1.7-IN-3 Chemical Structure

    CAS No. : 1788872-06-9

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    Description

    Nav1.7-IN-3 is a selective, orally bioavailable voltage-gated sodium channel Nav1.7 inhibitor with an IC50 of 8 nM. Pain relief. Limited CNS penetration[1].

    IC50 & Target

    IC50: 8 nM (Nav1.7)[1]

    In Vivo

    Nav1.7-IN-3 (compound 5) shows excellent potency, selectivity, behavioral efficacy in a rodent pain model (30 mg/kg, oral, 35 minutes), and efficacy in a mouse itch model (30 mg/kg, oral, 30 minutes)[1].

    Animal Model: C57BL/6 male mice (n=8/group, 25-30g)
    Dosage: 1, 3, and 10 mg/kg
    Administration: Oral (0-35 mintues)
    Result: Nav1.7-IN-3 demonstrates statistically significant, dose-dependent reversal of these effects in the acute phase of the experiment (0-5 min period post formalin injection) and the tonic phase of the experiment (20-35 min period post formalin injection) with full reversal of formalin effects in the tonic phase[1]
    Solvent & Solubility
    In Vitro: 

    10 mM in DMSO

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.3205 mL 11.6023 mL 23.2045 mL
    5 mM 0.4641 mL 2.3205 mL 4.6409 mL
    10 mM 0.2320 mL 1.1602 mL 2.3205 mL
    *Please refer to the solubility information to select the appropriate solvent.
    References
    Molecular Weight

    430.95

    Formula

    C??H??ClFN?O?S?

    CAS No.

    1788872-06-9

    SMILES

    FC1=C(S(=O)(NC2=NC=CS2)=O)C=C(Cl)C(NCC34CCCN3CCC4)=C1

    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.

    Shipping

    Room temperature in continental US; may vary elsewhere

    • 摩尔计算器

    • 稀释计算器

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass   Concentration   Volume   Molecular Weight *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2

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    产品名称:
    Nav1.7-IN-3
    目录号:
    HY-101789
    需求量:

    Nav1.7-IN-3

    Cat. No.: HY-101789

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