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    1. Metabolic Enzyme/Protease
    2. HIF/HIF Prolyl-Hydroxylase

    TP0463518 

    目录号: HY-112144
    产品使用指南

    TP0463518 是一种有效的缺氧诱导因子脯氨酰羟化酶 (PHDs) 抑制剂,作用于人 PHD2Ki 值为 5.3 nM。TP0463518 还抑制人 PHD1/PHD3IC50 分别为 18 和 63 nM,以及猴 PHD2,IC50 值为 22 nM。

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    TP0463518 Chemical Structure

    TP0463518 Chemical Structure

    CAS No. : 1558021-37-6

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    Description

    TP0463518 is a potent hypoxia-inducible factor prolyl hydroxylases (PHDs) inhibitor with a Ki value of 5.3 nM for human PHD2. TP0463518 also inhibits human PHD1/PHD3 with IC50s of 18 and 63 nM as well as monkey PHD2 with an IC50 value of 22 nM[1].

    Solvent & Solubility
    In Vitro: 

    10 mM in DMSO

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.3157 mL 11.5786 mL 23.1573 mL
    5 mM 0.4631 mL 2.3157 mL 4.6315 mL
    10 mM 0.2316 mL 1.1579 mL 2.3157 mL
    *Please refer to the solubility information to select the appropriate solvent.
    References
    Molecular Weight

    431.83

    Formula

    C??H??ClN?O?

    CAS No.

    1558021-37-6

    SMILES

    ClC(C=C1)=CC=C1OC2=NC=C(CN3C(C(C(NCC(O)=O)=O)=C(O)CC3)=O)C=C2

    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.

    Shipping

    Room temperature in continental US; may vary elsewhere

    • 摩尔计算器

    • 稀释计算器

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass   Concentration   Volume   Molecular Weight *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2

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    产品名称:
    TP0463518
    目录号:
    HY-112144
    需求量:

    TP0463518

    Cat. No.: HY-112144

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