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    1. Stem Cell/Wnt
    2. β-catenin

    β-catenin

    β-catenin is a dual function protein, regulating the coordination of cell–cell adhesion and gene transcription. In humans, the CTNNB1 protein is encoded by the CTNNB1 gene. β-catenin is a subunit of the cadherin protein complex and acts as an intracellular signal transducer in the Wnt signaling pathway. It is a member of the catenin protein family and homologous to γ-catenin. Mutations and overexpression of β-catenin are associated with many cancers, including hepatocellular carcinoma, colorectal carcinoma, lung cancer,malignant breast tumors, ovarian and endometrial cancer. β-catenin is regulated and destroyed by the beta-catenin destruction complex, and in particular by the adenomatous polyposis coli (APC) protein, encoded by the tumour-suppressing APC gene. Therefore genetic mutation of the APC gene is also strongly linked to cancers, and in particular colorectal cancer resulting from familial adenomatous polyposis (FAP).

    β-catenin 相关产品 (17):

    Cat. No. Product Name Effect Purity
    • HY-15147
      XAV-939 Inhibitor 98.04%
      XAV-939是端锚聚合酶 (tankyrase (TNKS)) 抑制剂,也是间接的 Wnt/β-catenin signaling 抑制剂。抑制 TNKS1 和 TNKS2 的 IC50 分别为 5 和 2 nM。
    • HY-15597
      Salinomycin Inhibitor >98.0%
      Salinomycin是具有强大的抗菌 (anti-bacterial) 活性的抗球虫药,和靶向人类癌症干细胞的新型抗癌剂。
    • HY-17577
      Berberine chloride hydrate Activator 99.56%
      Berberine chloride hydrate是从一些植物中提取的生物碱,具有多种生物功能,包括胰岛素敏化,抗炎和抗氧化活性。它是 AMPK 的活化剂。
    • HY-101090
      KYA1797K Inhibitor >98.0%
      KYA1797K是有效,选择性的 Wnt/β-catenin 抑制剂,IC50 值为0.75 μM。
    • HY-15721
      FH535 Inhibitor 99.93%
      FH535 是 Wnt/β-cateninPPAR 的抑制剂,具有抗肿瘤活性。
    • HY-111760
      NRX-252262 Inhibitor
      NRX-252262 是一种有效的 β-Catenin 与 同源 E3 ligase SCFβ-TrCP 的相互作用增强剂,能够促进 β-catenin 的降解,EC50 值为 3.8 nM。
    • HY-101085
      SKL2001 Agonist 98.08%
      SKL2001 是 Wnt/β-catenin 信号通路的激动剂,具有抗肿瘤活性。
    • HY-11035
      WAY-262611 Agonist 99.08%
      WAY-262611是无翼的β-联蛋白激动剂,可增加骨形成速率,在TCF-荧光素酶测定实验中的EC50值为0.63 μM。
    • HY-101486
      LF3 Antagonist 98.58%
      LF3是β-Catenin/TCF4相互作用的拮抗剂,具有抗肿瘤活性。IC50值为1.65 μM。
    • HY-101130
      PNU-74654 Inhibitor 99.60%
      PNU-74654是Wnt/β-catenin通路的的抑制剂,在NCI-H295 细胞中的IC50值为129.8 μM。
    • HY-16910
      WIKI4 Inhibitor 99.77%
      WIKI4是Wnt/_beta_-catenin信号转到抑制剂,EC50值约75nM。
    • HY-102028
      KY1220 >98.0%
      KY1220作用于 Wnt/β-catenin 靶点,使β-catenin 和 Ras不稳定。在HEK293报告细胞中的IC50 值为2.1 μM。
    • HY-B0012
      Pamidronic acid >98.0%
      Pamidronic acid 是用于治疗各种骨吸收类疾病的药物。
    • HY-32736
      Triptonide Inhibitor 98.65%
      Triptonide(NSC 165677; PG 492)从雷公藤中提取,抑制由伴刀豆球蛋白A或脂多糖诱导的鼠脾细胞增殖。
    • HY-12319A
      Cardiogenol C hydrochloride Activator
      Cardiogenol C盐酸盐是一种细胞渗透性的嘧啶化合物, 有效诱导胚胎干细胞分化为心肌 (EC50= 100 nM)。
    • HY-B1057
      Nefopam hydrochloride Inhibitor 99.06%
      Nefopam是中枢性但非阿片类镇痛药, 缓解中度和重度疼痛。
    • HY-18258
      Berberine chloride Activator
      Berberine盐酸盐能有效的抑制多种癌细胞增殖,促进凋亡,能影响MAPK和Wnt/_beta_-catenin通路。
    Isoform Specific Products

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    Sorry. There is currently no product that acts on isoform together.

    Please try each isoform separately.

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