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    1. Metabolic Enzyme/Protease
    2. 15-PGDH

    15-PGDH

    15-PGDH (15-Hydroxyprostaglandin dehydrogenase) is a tumor suppressor in breast, colon, liver, lung, and pancreas since decreased expression of this enzyme is associated with increased tumorigenesis. 15-PGDH metabolizes intracellular PGE2 so that this ligand is unable to bind EP receptors, which results in suppression of PGE2 signaling.

    The tumor suppressor 15-PGDH is the key enzyme in prostaglandin E2 catabolism and is down-regulated in colorectal cancer (CRC) tissue. Canonical Wnt signaling is frequently elevated in colon cancers and has been shown to down-regulate 15-PGDH expression.

    Inhibition of 15-PGDH, a prostaglandin-degrading enzyme, potentiates tissue regeneration in multiple organs in mice. 15-PGDH acts in vivo as a negative regulator of prostaglandin levels and activity, provides a candidate target.

    15-PGDH 相关产品 (1):

    Cat. No. Product Name Effect Purity
    • HY-16968
      SW033291 Inhibitor 99.62%
      SW033291是15-PGDH小分子抑制剂,Ki值0.1nM,组织修复功能。
    Isoform Specific Products

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