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    1. Metabolic Enzyme/Protease
    2. 5-Lipoxygenase


    5-Lipoxygenase (5-LOX or 5-LO) is an enzyme that in humans is encoded by the ALOX5 gene. 5-lipoxygenase is a member of the lipoxygenase family of enzymes. It transforms EFAs into leukotrienes and is a current target for pharmaceutical intervention in a number of diseases. 5-LO catalyzes oxidation of AA at the 5-position to yield 5-HpETE. 5-LO then converts 5-HpETE to leukotriene A4. Recently, oxidized lipid products of 5-LO have been measured in membranes of neutrophils in the form of esterified-5-HETE phospholipids. These novel products have biological activities including inhibition of neutrophil extracellular traps. 5-LO is a target for pharmaceutical intervention in CAD. Some people with variant alleles for 5-LO are at elevated risk for CAD. 5-LO is expressed in brain cells and may participate in neuropathologic processes.

    5-Lipoxygenase 相关产品 (27):

    Cat. No. Product Name Effect Purity
    • HY-13419
      U-73122 Inhibitor 98.17%
      U-73122 是有效的 磷脂酶C (phospholipase C),磷脂酶A2 (phospholipase A2) 和 5-脂氧合酶 (5-LO (5-lipoxygenase)) 抑制剂。
    • HY-14164
      Zileuton Inhibitor 99.93%
    • HY-N0198
      Nordihydroguaiaretic acid Inhibitor 99.78%
      Nordihydroguaiaretic acid 是一种 5-脂氧合酶 (5LOX) (IC50=8±3 μM) 和酪氨酸激酶抑制剂。
    • HY-12341
      ML355 Inhibitor 98.28%
    • HY-19807
      Indirubin-3'-monoxime Inhibitor 99.95%
      Indirubin-3'-monoxime 是一种有效的 GSK-3β 抑制剂,对 5-Lipoxygenase 的抑制作用较弱,IC50 值分别为 22 nM 和 7.8-10 μM;Indirubin-3'-monoxime 同时对 CDK5/p25 和 CDK1/cyclin B 也有较强作用,IC50 值分别为 100 和 180 nM。
    • HY-12886
      Docebenone Inhibitor
      Docebenone (AA 861) 是一种有效的、选择性的和有口服活性的 5-脂氧合酶 (5-LO) 抑制剂。
    • HY-N0172
      Caffeic acid Inhibitor 98.80%
      Caffeic acid 是 TRPV1 离子通道和 5-脂氧合酶 (5-LO) 的抑制剂。
    • HY-N2176
      S-(+)-Marmesin Inhibitor 99.04%
      S-(+)-Marmesin 是一种天然的香豆素,具有 COX-2/5-LOX 双重抑制作用。
    • HY-A0060
      Malotilate Inhibitor 99.54%
    • HY-N1881
      4',5-Dihydroxyflavone Inhibitor
      4',5-Dihydroxyflavone 是大豆 LOX-1/α-glucosidase 的抑制剂,其对大豆 LOX-1 的 Ki 值为102.6 μM,对酵母 α-glucosidase 的 IC50 值为 66 μM。
    • HY-14164A
      Zileuton sodium Inhibitor
      Zileuton sodium 是一种有效的,选择性的 5-lipoxygenase 抑制剂,具有抗炎的作用。
    • HY-U00024
      Enazadrem Inhibitor
      Enazadrem 是有效的 5-脂氧合酶 (5-lipoxygenase) 抑制剂,具有抗炎功效。
    • HY-101579
      LY 178002 Antagonist
      LY 178002 是一种有效的 5-lipoxygenasephospholipase A2 抑制剂,对 5-lipoxygenase 的 IC50 值为 0.6 μM,能够抑制人多形核白细胞产生 LTB4,同时可相对较弱地抑制 cyclooxygenase 的活性。
    • HY-U00022
      RWJ 63556 Inhibitor
      RWJ 63556 是一种可口服的 COX-2 selective/5-lipoxygenase 抑制剂,具有抗炎活性。
    • HY-19212
      S-2474 Inhibitor
      S-2474 是 COX-25-lipoxygenase 的抑制剂,在人完整的细胞中,对 COX-2 和 COX-1 的 IC50 值分别为 11 nM 和 27 μM,为一种非甾体抗炎药。
    • HY-100148
      ICI 211965 Inhibitor
      ICI 211965 是一个有选择性且口服有效的 5-脂氧合酶 (5-LPO) 抑制剂。
    • HY-101945
      A-69412 Inhibitor
      A-69412 是一种特异性的、亲水性5-脂氧合酶 (5-LO) 的可逆抑制剂。
    • HY-U00260
      CMI977 Inhibitor
      CMI977 是一种有效的 5-Lipoxygenase (5-LO) 抑制剂。
    • HY-U00347
      COX/5-LO-IN-1 Inhibitor
      COX/5-LO-IN-1 是 cylooxygenase5-lipoxygenase 的抑制剂,用于炎症性和过敏性疾病的研究。
    • HY-U00156
      Lonapalene Inhibitor
      Lonapalene (RS4317) 是一种有效的 5-脂氧合酶 (5-LO) 抑制剂。
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