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    1. Neuronal Signaling
    2. AChE


    Acetylcholinesterase (AChE or acetylhydrolase) is a hydrolase that hydrolyzes the neurotransmitter acetylcholine. AChE is found at mainly neuromuscular junctions and cholinergic brain synapses, where its activity serves to terminate synaptic transmission. It belongs tocarboxylesterase family of enzymes. It is the primary target of inhibition by organophosphorus compounds such as nerve agents and pesticides. AChE has a very high catalytic activity - each molecule of AChE degrades about 25000 molecules ofacetylcholine (ACh) per second, approaching the limit allowed by diffusion of the substrate. ACh is released from the nerve into the synaptic cleft and binds to ACh receptors on the post-synaptic membrane, relaying the signal from the nerve. AChE, also located on the post-synaptic membrane, terminates the signal transmission by hydrolyzing ACh. The liberated choline is taken up again by the pre-synaptic nerve and ACh is synthetized by combining with acetyl-CoA through the action of choline acetyltransferase.

    AChE 相关产品 (40):

    Cat. No. Product Name Effect Purity
    • HY-76299
      Galanthamine Inhibitor 99.43%
      Galanthamine 是一种有效的乙酰胆碱酯酶 (AChE) 抑制剂,IC50 为 500 nM。
    • HY-B0034
      Donepezil Hydrochloride Inhibitor 99.97%
      Donepezil(E 2020)盐酸盐是非竞争性的AChE抑制剂,能穿过血脑屏障,增加皮质中的乙酰胆碱水平。
    • HY-B0943
      Malathion Inhibitor >98.0%
    • HY-17552
      sn-Glycero-3-phosphocholine Activator >98.0%
      L-Alpha glycerylphosphorylcholine (alpha-GPC, choline alfoscerate)是存在于脑和奶中的天然胆碱化合物,也是拟副交感神经乙酰胆碱前体。
    • HY-17368
      Rivastigmine Inhibitor 99.39%
      Rivastigmine酒石酸盐是胆碱酯酶抑制剂,IC50为5.5 uM,还能抑制丁酰胆碱酯酶和乙酰胆碱酯酶。
    • HY-B1626A
      Demecarium Bromide Inhibitor
      Demecarium Bromide (BC-48) 是一种有效的 cholinesterase 抑制剂,Kiapp 值为 0.15 μM。Demecarium Bromide (BC-48) 用作青光眼治疗剂。
    • HY-N0226
      Epiberberine Inhibitor
      Epiberberine 是从黄连中得到的生物碱,为有效的 AChEBChE 抑制剂,和非竞争性的 BACE1 抑制剂,IC50 值分别为 1.07,6.03 和 8.55 μM。Epiberberine 具有抗氧化作用,能够清除 ONOO- (IC50,16.83 μM),对阿尔滋海默症和糖尿病有潜在治疗作用。在 3T3-
    • HY-B0942
      Benzethonium chloride Inhibitor >98.0%
      Benzethonium chloride作用于在爪蟾卵母细胞,抑制人重组α7和α4β2神经元烟碱性乙酰胆碱受体。
    • HY-A0009
      Galanthamine hydrobromide Inhibitor 99.53%
      Galanthamine氢溴酸盐是长效的中心活性的乙酰胆碱酯酶(AChE)抑制剂,IC50为410 nM,同时是神经元烟碱乙酰胆碱受体的变构增强剂。
    • HY-17388
      (±)-Huperzine A Inhibitor >98.0%
      Huperzine A是传统中草药中提取的活性石松属生物碱,是可逆的乙酰胆碱酯酶(ACE)抑制剂,在中国被广泛的运用于阿尔茨海默病。
    • HY-B2244
      Tacrine hydrochloride hydrate Inhibitor 99.98%
      Tacrine hydrochloride hydrate 是乙酰胆碱酯酶 (AChE) 和丁酰胆碱酯酶 (BChE) 的抑制剂,其 IC50 值分别为 31 nM 和 25.6 nM。
    • HY-14566
      Donepezil Inhibitor 99.87%
      Donepezil(E 2020)是AChE抑制剂,对bAChE和hAChE的IC50分别为8.12 nM和11.6 nM。
    • HY-17387
      (-)-Huperzine A Inhibitor >98.0%
      Huperzine A是传统中草药中提取的活性石松属生物碱,是可逆的乙酰胆碱酯酶(ACE)抑制剂,在中国被广泛的运用于阿尔茨海默病。
    • HY-N0342
      Scopoletin Inhibitor 99.57%
      Scopoletin 是一种乙酰胆碱酯酶 (AChE) 抑制剂。
    • HY-B0207A
      Pyridostigmine bromide Inhibitor >98.0%
    • HY-B0949
      Protriptyline hydrochloride Inhibitor 99.91%
    • HY-N0285
      Imperatorin Inhibitor 98.11%
      Imperatorin 是一种有效的 NO synthesis 抑制剂,IC50 为 9.2 μmol,也是 BChE 抑制剂,IC50 为 31.4 μmol。Imperatorin 是 TRPV1 的微弱激动剂,EC50 为 12.6±3.2 μM。
    • HY-N0226A
      Epiberberine chloride Inhibitor 99.60%
      Epiberberine chloride 是从黄连中得到的生物碱,为有效的 AChEBChE 抑制剂,和非竞争性的 BACE1 抑制剂,IC50 值分别为 1.07,6.03 和 8.55 μM。Epiberberine chloride 具有抗氧化作用,能够清除 ONOO- (IC50,16.83 μM),对阿尔滋海默症和糖尿病有潜在治疗作用
    • HY-11017
      Rivastigmine tartrate Inhibitor 98.53%
      Rivastigmine酒石酸盐是胆碱酯酶抑制剂,IC50为5.5 uM,还能抑制丁酰胆碱酯酶和乙酰胆碱酯酶。
    • HY-B1200
      Pralidoxime chloride Activator >99.0%
      Pralidoxime chloride属于肟类化合物, 有效治疗有机磷中毒,对中毒乙酰胆碱酯酶具有恢复作用。
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