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    1. Antibody-drug Conjugate/ADC Related
    2. ADC Cytotoxin

    ADC Cytotoxin

    Antibody-drug conjugates (ADCs) represent a novel class of cancer therapeutics. Their design involves a tumor-specific antibody, a linker and a cytotoxic payload. The payload in ADCs are highly potent cytotoxins, exerting their effects on critical cellular processes required for survival. Typically, the cytotoxins used in ADCs are a 100-1000 times more potent than regular chemotherapeutics and preferably have sub-nanomolar potency. Most compounds in current clinical testing utilize either maytansine derivatives (DM1/DM4) or auristatins (MMAE/ MMAF), which are both microtubule inhibitors. These typically induce apoptosis in cells undergoing mitosis by causing cell cycle arrest at G2/M. More recent work shows that microtubule inhibitors may also disrupt non-dividing cells in interphase. Other classes of cytotoxins used in ADCs include enediynes (Calicheamicin ), duocarmycin derivatives, pyrrolobenzodiazepines (PBDs) and indolinobenzodiazepines, all of which target the minor groove of DNA, and quinoline alkaloids (SN-38), which inhibit topoisomerase. For example, the potent cytotoxic drug doxorubicin and daunorubicin may interact with DNA by intercalation.

    ADC Cytotoxin 相关产品 (38):

    Cat. No. Product Name Effect Purity
    • HY-15142
      Doxorubicin hydrochloride 99.47%
      Doxorubicin hydrochloride是一种有细胞毒性的蒽环类抗生素,用于治疗多种癌症。 Doxorubicin 在癌细胞中起作用的可能机制是嵌入 DNA 和破坏 topoisomerase-II 介导的DNA修复。
    • HY-13316
      Mitomycin C 98.89%
      Mitomycin C是一种抗肿瘤药物和抗生素,可有效的抑制DNA合成 (DNA synthesis)。
    • HY-B0015
      Paclitaxel 99.97%
      Paclitaxel (Taxol) 是一种有效的抗癌药物,可以促进微管 (microtubule (MT)) 组装,抑制MT解聚,并改变有丝分裂和细胞增殖所需的微管动力学。
    • HY-19610
      alpha-Amanitin 99.79%
      alpha-Amanitin是几种致命毒蘑菇的主要毒素,通过抑制 RNA聚合酶II 发挥其毒性作用。
    • HY-15162
      Monomethyl auristatin E 99.94%
      Monomethyl auristatin E (MMAE) 是海兔毒素10的合成衍生物,通过抑制微管蛋白聚合而起到有效的有丝分裂抑制作用。 MMAE广泛用作细胞毒性成分制作抗体-药物偶联物 (ADCs) 以治疗癌症。
    • HY-107769
      Duocarmycin TM 98.99%
      Duocarmycin TM 是一种非常有效的有抗肿瘤活性的抗生素。
    • HY-16261B
      MC-DOXHZN hydrochloride
      MC-DOXHZN hydrochloride 是 Doxorubicin 的白蛋白结合前药,具有酸敏感性。
    • HY-14519
      Methotrexate 99.75%
      Methotrexate是一种叶酸拮抗剂,在体外试验中 IC50 为 78 nM。
    • HY-16560
      Campathecin 98.26%
      Campathecin 是有效的 DNA拓扑异构酶 I 抑制剂,IC50 值为 679 nM。
    • HY-16261
      Aldoxorubicin (INNO-206) 是多柔比星的白蛋白结合前药,在酸性条件下从白蛋白中释放出来。 Aldoxorubicin (INNO-206) 在各种癌细胞系和小鼠肿瘤模型中具有有效的抗肿瘤活性。
    • HY-13062
      Daunorubicin Hydrochloride 99.27%
      Daunorubicin hydrochloride是具有有效抗肿瘤活性的DNA拓扑异构酶II抑制剂。
    • HY-19609
      Calicheamicin 98.44%
      Calicheamicin 是一种有效的细胞毒性试剂,可引起DNA双链断裂。
    • HY-15162A
      D8-MMAE 98.31%
    • HY-13061
      Daun02 98.56%
    • HY-15579A
      MMAF Hydrochloride 99.89%
      MMAF hydrochloride是抑制细胞分裂的抗微管蛋白剂; 抑制H3397细胞生长的IC50值为105 nM。
    • HY-15584
      Taltobulin 99.90%
      Taltobulin (HTI-286; SPA-110)是Hemiasterlin类似物,微管蛋白抑制剂和抗体药物偶连体毒素组分(ADCs cytotoxin)。
    • HY-16700
      PNU-159682是一种高效的蒽环类新霉素代谢产物,具有突出的细胞毒性,是一种有效的 ADC细胞毒素
    • HY-15583
      Auristatin F 98.35%
      Auristatin F是细胞毒性分子,微管蛋白修饰分子,强效抗肿瘤活性,MMAF的类似物以及在抗体药物偶连体开发中作为毒素分子。
    • HY-15739
      Ansamitocin P-3 >98.0%
      Ansamitocin P-3 是一种微管 (microtubule)抑制剂。Ansamitocin P-3 是一种大环抗肿瘤抗生素。
    • HY-19474
      Maytansinol 98.15%
      Maytansinol抑制微管组装且诱导微管解, 与辐射联用, 用于果蝇和人类癌细胞。
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