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    1. Protein Tyrosine Kinase/RTK
    2. ALK


    ALK (Anaplastic lymphoma kinase) is encoded by the ALK gene. ALK is a membrane associated tyrosine kinase receptor of the insulin receptor superfamily. The function of the full-length ALK receptor is poorly understood. It has a probable role in the central and peripheral nervous system development and maintenance. ALK is a dependence receptor, which may exert antagonist functions, proapoptotic or antiapoptotic, depending on the absence or presence of a ligand. Dependence receptors have a potential role in cancer and development. Ligands available for this demonstration were agonist anti-ALK antibodies. ALK is still an orphan receptor, given the high level of controversy about pleiotrophin and midkine.

    ALK 相关产品 (32):

    Cat. No. Product Name Effect Purity
    • HY-50878
      Crizotinib Inhibitor 99.97%
      Crizotinib是有效的 c-MetALK 抑制剂,在细胞试验中的 IC50 值分别为11 nM 和 24 nM。
    • HY-12857
      Brigatinib Inhibitor 99.86%
      Brigatinib 是有效,选择性的 ALK 抑制剂,IC50 值为 0.6 nM。
    • HY-13011
      Alectinib Inhibitor 99.34%
      Alectinib (CH5424802) 是一种有效,选择性和可口服的 ALK 抑制剂,IC50 为1.9 nM。
    • HY-12215
      Lorlatinib Inhibitor 99.83%
      Lorlatinib (PF-064639220 是一种有效的,ALK/ROS1 双抑制剂,抑制 ROS1,野生ALK 和 突变ALK (L1196M) 的 Ki 分别为0.02 nM,0.07 nM 和 0.7 nM。
    • HY-15656
      Ceritinib Inhibitor 99.97%
      Ceritinib (LDK378) 是有效且特异性的 ALK 抑制剂,IC50 为 0.2 nM。
    • HY-111416
      WY-135 Inhibitor
      WY-135是ALK (IC50=1.4 nM) 和 ROS1 (IC50=1.1 nM) 的双抑制剂。
    • HY-112155
      MS4078 Inhibitor
      MS4078 是间变性淋巴瘤激酶 (ALK) PROTAC (降解物),结合 ALK,Kd 为 19 nM。
    • HY-112156
      MS4077 Inhibitor
      MS4077 是间变性淋巴瘤激酶 (ALK) PROTAC (降解物),结合 ALK, Kd 为 37 nM。
    • HY-12678
      Entrectinib Inhibitor 99.61%
      Entrectinib是有效,有口服活性的Trk, ROS1, 和ALK抑制剂;抑制TrkA, TrkB, TrkC, ROS1和 ALK的IC50值分别为1, 3, 5, 12 和7 nM。
    • HY-10192
      NVP-TAE 684 Inhibitor 99.40%
      NVP-TAE 684 是一种高效的,选择性的 ALK 抑制剂,阻止 ALCL 衍生的 ALK 依赖性细胞株的生长,IC50 值为 2-10 nM。
    • HY-50878A
      Crizotinib hydrochloride Inhibitor 99.86%
      Crizotinib hydrochloride 是有效的 c-MetALK 抑制剂,在细胞试验中,IC50 值分别为 11 nM 和 24 nM。
    • HY-15609
      AZD-3463 Inhibitor 98.49%
    • HY-13464
      ALK-IN-1 Inhibitor 99.96%
      ALK-IN-1是ALK激酶高效选择性抑制剂,出自专利US20140066406 A1。
    • HY-13011A
      Alectinib Hydrochloride Inhibitor 99.95%
      Alectinib Hydrochloride (CH5424802 Hydrochloride) 是一种有效、选择性、可口服的 ALK 抑制剂,IC50 值为 1.9 nM,KD) 值为 2.4 nM。
    • HY-103022
      Repotrectinib Inhibitor 99.91%
      Repotrectinib (TPX-0005) 是一种有效的 ALK/ROS1/TRK 抑制剂,对 SRC,野生型 WT ALK,突变型 ALK G1202R 和 ALK L1196M 的 IC50 值分别为 5.3 nM,1.01 nM,1.26 nM 和 1.08 nM。
    • HY-15841
      CEP-37440 Inhibitor 99.87%
      CEP-37440是新型FAK和ALK双重抑制剂,IC50分别为2.3 nM和120 nM。
    • HY-13020
      GSK1838705A Inhibitor 98.99%
      GSK1838705A是高效,可逆的 IGF-IR 和胰岛素受体 (insulin receptor) 抑制剂,IC50 值分别为2.0 和 1.6 nM。也可抑制 ALKIC50 值为0.5 nM。
    • HY-15656A
      Ceritinib dihydrochloride Inhibitor 99.86%
      Ceritinib dihydrochloride (LDK378 dihydrochloride) 是 ALK 抑制剂,IC50 为 0.2 nM,比对 IGF-1R 和 InsR 的抑制性高 40 倍和 35 倍。
    • HY-16590
      X-376 Inhibitor 98.02%
      X-376 是一种有效的双重的 ALK/MET 抑制剂,IC50 分别为 0.61 nM 和 0.69 nM。
    • HY-13326
      ASP3026 Inhibitor 99.76%
      ASP3026是高活性ALK抑制剂,IC50为3.5 nM。
    Isoform Specific Products

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    Please try each isoform separately.