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    1. Cell Cycle/DNA Damage
    2. ATM/ATR


    ATM/ATR are members of the PI3 family of serine-threonine kinases and function as essential links between the sensors and effectors of the DNA damage response. The roles of ATM and ATR partially overlap and are cooperative; however they are also known to play distinct roles in protecting the cell from DNA damage. ATM is mostly responsible for sending signals from DSBs (double-strand breaks) induced by ionizing radiation while the closely related ATR responds to UV damage or stalled replication forks. ATM and ATR are known to phosphorylate common as well as specific substrates to activate checkpoint signaling. The G1, S, and G2 cell cycle checkpoints are primarily regulated by the ATM (ataxia telangiectasia, mutated) and ATR (ATM and Rad3-related) protein kinases.

    ATM/ATR Isoform Specific Products:

    • ATM

    • ATR

    ATM/ATR 相关产品 (17):

    Cat. No. Product Name Effect Purity
    • HY-10197
      Wortmannin Inhibitor 99.85%
      Wortmannin是可渗透细胞,不可逆的 (PI3Ks) 抑制剂,IC50 为3 nM。 Wortmannin还可抑制 DNA-PKATMIC50分别为16 nM 和 150 nM。
    • HY-19323
      Ceralasertib Inhibitor 99.76%
      Ceralasertib (AZD6738) 是有效地 ATR 激酶抑制剂,IC50 值为 1 nM。
    • HY-13902
      Berzosertib Inhibitor 99.22%
      Berzosertib (VE-822) 是一种 ATR 抑制剂,Ki值小于0.2 nM。也可抑制 ATMKi 为 34 nM。
    • HY-12016
      KU-55933 Inhibitor 99.67%
      KU-55933 是有效的 ATM 抑制剂,IC50Ki 值分别为 12.9 和 2.2 nM;对 ATM 的选择性比对 DNA-PK,PI3K/PI4K,ATR 和 mTOR 高。
    • HY-14731
      VE-821 Inhibitor 99.47%
      VE-821 是一种有效的 ATP 竞争性的 ATR 抑制剂,Ki/IC50 为 13 nM/26 nM。
    • HY-112614
      ATM Inhibitor-1 Inhibitor
      ATM Inhibitor-1 是一种有效、选择性、可口服的 ATM 抑制剂,IC50 值为 0.7 nM,对 mTOR (IC50,21 μM),DNAPK (IC50,2.8 μM),PI3Kα (IC50,3.8 μM),PI3Kβ (IC50,10.3 μM),PI3Kγ (IC50,3 μM) 和 PI3Kδ (IC50
    • HY-101566
      BAY-1895344 Inhibitor
      BAY-1895344 是一种有效、可口服、选择性的 ATR 抑制剂,IC50 值为 7 nM。具有抗肿瘤活性。
    • HY-12061
      KU-60019 Inhibitor 98.03%
      KU-60019 是一种 ATM 激酶特异性的抑制剂,IC50 为 6.3 nM。
    • HY-100016
      AZD0156 Inhibitor 99.60%
      AZD0156是可口服,高效,选择性的 ATM 抑制剂,IC50 为0.58 nM。
    • HY-109566
      AZD1390 Inhibitor 99.81%
      AZD1390 是一种 ATM 抑制剂。
    • HY-15557
      AZ20 Inhibitor 99.84%
      AZ20 是一种有效的,选择性的 ATR 抑制剂,IC50 值为 5 nM;同时可抑制 mTOR 活性,IC50 值为 38 nM。
    • HY-101566A
      BAY-1895344 hydrochloride Inhibitor 99.04%
      BAY-1895344 hydrochloride 是一种有效、可口服、选择性的 ATR 抑制剂,IC50 值为 7 nM。具有抗肿瘤活性。
    • HY-11002
      CP-466722 Inhibitor 98.40%
      CP-466722 是一种可逆的 ATM 抑制剂,IC50 值为 4.1 μM,但对 PI3K,PIKK 家族蛋白没有作用。
    • HY-15520
      CGK733 Inhibitor 99.93%
      CGK733 是一种有效的 ATM/ATR 抑制剂,用于癌症研究。
    • HY-15521
      ETP-46464 Inhibitor 99.13%
      ETP-46464 是一种有效的 mTORATR 抑制剂,IC50 分别为 0.6 和 14 nM。
    • HY-112305
      AZ32 Inhibitor 99.98%
      AZ32 是一种口服可利用的,可穿透血脑屏障的 ATM 抑制剂,IC50<6.2 nM。在细胞中抑制 ATM,IC50 为 0.31 μM。
    • HY-18650
      KU 59403 Inhibitor
      KU 59403 是 ATM 的一个有效抑制剂,其 IC50 值为 3 nM。
    Isoform Specific Products

    Your Search Returned No Results.

    Sorry. There is currently no product that acts on isoform together.

    Please try each isoform separately.