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    1. Metabolic Enzyme/Protease
    2. Acetyl-CoA Carboxylase

    Acetyl-CoA Carboxylase

    Acetyl-CoA carboxylase (ACC) is a biotin carboxylase that catalyzes the ATP-dependent condensation of acetyl-CoA and carbonate to form malonyl-CoA. The malonyl-CoA produced by ACC serves two major physiologic functions. It is an essential and rate-limiting substrate for de novo lipogenesis (DNL), and it acts as an allosteric inhibitor of the enzyme carnitine-palmitoyl transferase I (CPT-1). Acetyl-CoA carboxylase (ACC) inhibitors offer significant potential for the treatment of type 2 diabetes mellitus (T2DM), hepatic steatosis, and cancer.

    Acetyl-CoA carboxylase (ACC) in mammals is encoded by two related enzymes ACC1 and ACC2, which catalyze the ATP dependent carboxylation of acetyl-CoA to form malonyl-CoA. ACC1 encodes a cytoplasmic isoform that is thought to be the predominant isoform controlling FASyn, whereas ACC2 is tethered to the mitochondrial outer membrane, where localized malonyl-CoA production blocks CPT-1 function to prevent fatty acids from entering the mitochondria to undergo fatty acid oxidation (FAOxn).

    Acetyl-CoA Carboxylase 相关产品 (8):

    Cat. No. Product Name Effect Purity
    • HY-16901
      Firsocostat Inhibitor 98.72%
      Firsocostat (ND-630; GS-0976; NDI-010976) 是乙酰辅酶A羧化酶 (ACC) 抑制剂,抑制人类 ACC1 和 ACC2 的 IC50 值分别为2.1和6.1 nM。
    • HY-101842
      ND-646 Inhibitor 98.39%
      ND-646 是一种有效的乙酰辅酶 A 羧化酶 (ACC) 抑制剂,抑制重组 hACC1 和 hACC2,IC50 分别为 3.5 nM 和 4.1 nM。
    • HY-101068
      TOFA Inhibitor >98.0%
      TOFA (RMI14514;MDL14514)是乙酰辅酶A羧化酶-α (ACCA )的变构抑制剂。
    • HY-15259A
      CP-640186 hydrochloride Inhibitor 99.40%
      CP-640186 hydrochloride是一种有效且可透过细胞的乙酰辅酶A羧化酶 (ACC)抑制剂,抑制大鼠肝脏ACC1和大鼠骨骼肌ACC2的 IC50为53 nM和61 nM。
    • HY-12942
      PF-05175157 Inhibitor 98.74%
      PF-05175157 是一种广谱乙酰辅酶 A 羧化酶 (ACC) 抑制剂,对 ACC1 (human),ACC2 (human), ACC1 (rat) 和 ACC2 (rat) 的 IC50 值分别为 27.0, 33.0, 23.5 和 50.4 nM。
    • HY-17641
      Olumacostat glasaretil Inhibitor 98.78%
      Olumacostat glasaretil是乙酰辅酶A羧化酶(ACC)的小分子抑制剂。
    • HY-107709
      MK-4074 Inhibitor 98.72%
      MK-4074是乙酰辅酶A羧化酶 (acetyl-CoA carboxylase) 的肝特异性抑制剂,IC50 值约为3nM。
    • HY-15259
      CP-640186 Inhibitor
      CP-640186是乙酰辅酶A羧化酶(ACCase)抑制剂,对鼠肝ACCase1和骨骼肌ACCase2的IC50s分别为53 nM和61 nM,比CP-610431有更好的代谢稳定性。
    Isoform Specific Products

    Your Search Returned No Results.

    Sorry. There is currently no product that acts on isoform together.

    Please try each isoform separately.