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    1. Signaling Pathways
    2. Metabolic Enzyme/Protease
    3. Aldehyde Dehydrogenase (ALDH)

    Aldehyde Dehydrogenase (ALDH)

    Aldehyde dehydrogenase 1 (ALDH1), which is a putative marker of breast cancer stem cells (CSCs), in triple negative breast cancer (TNBC) tissues.

    Mitochondrial aldehyde dehydrogenase (ALDH2) is a member of the 19-strong human aldehyde dehydrogenase family of NADP+-dependent enzymes.

    ALDH2, a mitochondrial enzyme responsible for metabolizing the major lipid peroxidation product, protects against acute ischemia/reperfusion injury and chronic heart failure. Activation of ALDH2, the main enzyme that catalyzes 4-HNE metabolism, is sufficient to protect the heart against acute ischemia-reperfusion injury.

    ALDH2 is a key detoxifying enzyme. ALDH2 is most commonly associated with its role in ethanol metabolism, catalyzing the oxidation of ethanol-derived acetaldehyde to acetate.

    Aldehyde Dehydrogenase (ALDH) 相关产品 (5):

    Cat. No. Product Name Effect Purity
    • HY-B0240
      Disulfiram Inhibitor 98.67%
      Disulfiram 是特异性的乙醛脱氢酶1型抗体 (ALDH1) 抑制剂,可以通过对酒精产生急性敏感性来治疗慢性酗酒。
    • HY-18936
      Alda-1 Agonist 99.81%
      Alda-1是有效的 ALDH2 激动剂,其激活野生型ALDH2并恢复近似野生型活性至ALDH2*2。
    • HY-18768
      NCT-501 Inhibitor 99.78%
      NCT-501 是一种茶碱类的有效醛脱氢酶 1A1 (ALDH1A1) 选择性抑制剂, 抑制 hALDH1A1 时 IC50 值为 40 nM, 选择性超过其它 ALDH 同工酶和其它脱氢酶 (作用于 hALDH1B1, hALDH3A1, 和 hALDH2 时, IC50值 >57 UM)。
    • HY-112277
      NCT-505 Inhibitor
      NCT-505 是一种有效的,选择性的乙醛脱氢酶 (aldehyde dehydrogenase (ALDH1A1)) 抑制剂,IC50 值为 7 nM,对 hALDH1A2,hALDH1A3,hALDH2,hALDH3A1 的抑制作用较弱,IC50 值分别为 >57,22.8,20.1,>57 μM。
    • HY-112278
      NCT-506 Inhibitor
      NCT-506 是一种口服生物可利用的醛脱氢酶 1A1 (ALDH1A1) 抑制剂,IC50 为 7 nM。
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