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    1. Neuronal Signaling
    2. Amyloid-β


    Amyloid-β (Aβ) denotes peptides of 36–43 amino acids that are crucially involved in Alzheimer's disease as the main component of theamyloid plaques found in the brains of Alzheimer patients. The peptides result from the amyloid precursor protein (APP), which is being cut by certain enzymes to yield Aβ. Amyloid-β molecules can aggregate to form flexible soluble oligomers which may exist in several forms. Amyloid-β peptide is due to overproduction of Aβ and/or the failure of clearance mechanisms. Amyloid-β self-aggregates into oligomers, which can be of various sizes, and forms diffuse and neuritic plaques in the parenchyma and blood vessels. Amyloid-β oligomers and plaques are potent synaptotoxins, block proteasome function, inhibit mitochondrial activity, alter intracellular Ca2+levels and stimulate inflammatory processes. Loss of the normal physiological functions of Aβ is also thought to contribute to neuronal dysfunction.

    Amyloid-β 相关产品 (47):

    Cat. No. Product Name Effect Purity
    • HY-B0988
      Deferoxamine mesylate Inhibitor >98.0%
      Deferoxamine mesylate是一种铁螯合剂,可将游离铁与稳定的复合物结合,防止其发生化学反应。
    • HY-P0128
      Amyloid beta-peptide(25-35) 98.03%
      Amyloid beta-peptide(25-35) 是阿尔茨海默氏淀粉样蛋白β肽的Aβ(25-35) 片段,在培养细胞中显示出神经毒性活性。
    • HY-19370
      FPS-ZM1 Inhibitor 99.70%
      FPS-ZM1是高亲和力的 RAGE 抑制剂,Ki 值为 25 nM。
    • HY-N0603
      Ginsenoside Rg3 Inhibitor >98.0%
      Ginsenoside Rg3 是红参的主要成分。Ginsenoside Rg3 抑制 Na+hKv1.4 通道,IC50 分别为 32.2±4.5 和 32.6±2.2 μM。Ginsenoside Rg3 还抑制 NF-κB 活性和 COX-2 表达。
    • HY-N0009
      Geniposide Antagonist 99.52%
      Geniposide是从栀子花中提取的环烯醚萜甙; 具有多种生物活性,例如抗糖尿病,抗氧化,抗增殖和神经保护活性。
    • HY-P1061A
      Colivelin TFA
      Colivelin (TFA) 是具有神经保护功能的多肽,也是 STAT3 的活化物。
    • HY-P1363
      Amyloid β-Peptide (1-42) human
      Amyloid β-Peptide (1-42) human 是由 42 个氨基酸组成的肽,其在阿尔茨海默病的发病机制中起关键作用。
    • HY-N0045
      Ginsenoside Rg1 Inhibitor >98.0%
      Ginsenoside Rg1 是人参的主要活性成分之一。Ginsenoside Rg1 通过降低大脑 水平来发挥作用。Ginsenoside Rg1 减少 NF-κB 核易位。
    • HY-17631A
      Edonerpic maleate Inhibitor 99.40%
      Edonerpic maleate 是一种新的神经营养剂,其可以抑制淀粉样蛋白 β 肽 ()。
    • HY-10009
      Semagacestat Inhibitor 98.83%
      Semagacestat 是一种 γ-secretase 抑制剂,抑制 β-amyloid (Aβ42),Aβ38Aβ40IC50 分别为 10.9,12 和 12.1 nM。也抑制 NotchIC50 为 14.1 nM。
    • HY-15560B
      Hoechst 34580 tetrahydrochloride Inhibitor 99.65%
      Hoechst 34580 tetrahydrochloride是一种细胞渗透性的荧光染料,用于DNA和核染色。
    • HY-P1388A
      β-Amyloid (1-42), rat TFA
      β-Amyloid (1-42), rat TFA 是由 42 个氨基酸组成的多肽,对海马切片有毒性,可用于阿尔兹海默症的研究。
    • HY-N0615
      Notoginsenoside R1 Inhibitor
      三七皂苷R1 (Notoginsenoside R1) 三七的主要活性成分,据报道有神经保护、抗高血压的作用。
    • HY-14537
      Latrepirdine dihydrochloride Inhibitor 99.75%
      Latrepirdine dihydrochloride 是一种神经活性化合物,对组胺受体 (histaminergic receptor),α-肾上腺素能受体 (α-adrenergic receptor) 和 5-羟色胺受体 (serotonergic receptor) 具有拮抗活性。Latrepirdine 刺激淀粉样前体蛋白 (APP) 分解代谢和 β-淀粉样蛋白 (amyloid-β, ) 分泌。
    • HY-14602
      Tramiprosate Inhibitor >98.0%
    • HY-N0602
      Ginsenoside Rg2 Inhibitor 99.24%
      Ginsenoside Rg2 是人参的主要活性成分之一。Ginsenoside Rg2 是一种 NF-κB 抑制剂。 Ginsenoside Rg2 还降低 1-42 积聚。
    • HY-15374
      Frentizole Inhibitor 99.01%
    • HY-111383
      LX2343 Inhibitor 99.86%
      LX2343 是一种 BACE1 酶抑制剂,IC50 值为 11.43±0.36 μM。LX2343 是一种非 ATP 竞争性的 PI3K 抑制剂,IC50 为 15.99±3.23 μM。LX2343 刺激自噬促进 清除。
    • HY-N0044
      Ginsenoside Re Inhibitor 98.04%
      Ginsenoside Re (Ginsenoside B2) 是一种 Panax notoginseng 提取物。Ginsenoside Re 可降低 β-淀粉样蛋白 ()。Ginsenoside Re 还通过抑制 JNKNF-κB 发挥抗炎作用。
    • HY-P1362
      Amyloid β Peptide (42-1)(human)
      Amyloid β Peptide (42-1)(human) 是淀粉样蛋白 β 肽 (1-42) 的无活性形式。淀粉样蛋白 β 肽 (1-42) 是由 42 个氨基酸组成的肽,其在阿尔茨海默病的发病机制中起关键作用。
    Isoform Specific Products

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