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    1. Immunology/Inflammation
    2. Aryl Hydrocarbon Receptor

    Aryl Hydrocarbon Receptor

    Aryl Hydrocarbon Receptor (AhR or AHR or ahr or ahR) is a protein that in humans is encoded by the AHR gene. The aryl hydrocarbon receptor is a ligand-activated transcription factor involved in the regulation of biological responses to planar aromatic (aryl) hydrocarbons, and regulates xenobiotic-metabolizing enzymes such as cytochrome P450s, most notably cyp 1A1.

    Aryl Hydrocarbon Receptor is a member of the family of basic helix-loop-helix transcription factors. AhR binds several exogenous ligands including natural plant flavonoids, polyphenolics and indoles, as well as synthetic polycyclic aromatic hydrocarbons and dioxin-like compounds. AhR is a cytosolic transcription factor that is normally inactive, binding to several co-chaperones. Upon ligand binding to chemicals such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), the chaperones dissociate resulting in AhR translocating into the nucleus and dimerizing with ARNT (AhR nuclear translocator), leading to changes in gene transcription.

    Aryl Hydrocarbon Receptor 相关产品 (14):

    Cat. No. Product Name Effect Purity
    • HY-15484
      Pifithrin-α hydrobromide Agonist 98.28%
      Pifithrin-α hydrobromide是 p53 抑制剂,可阻断其转录活性并阻止细胞凋亡。Pifithrin-α hydrobromide 同时为 aryl hydrocarbon receptor (AhR) 的激动剂。
    • HY-12684
      CH-223191 Antagonist 98.16%
      CH-223191是有效且特异性的芳烃受体(AhR) 拮抗剂。 CH-223191阻断TCDD与AhR的结合,IC50 为0.03 μM。
    • HY-15001
      StemRegenin 1 Antagonist 99.50%
      StemRegenin 1 是一种有效的芳香烃受体 (AhR) 拮抗剂,IC50 为 127 nM。
    • HY-12451
      FICZ Agonist 98.19%
      FICZ是有效的芳烃受体 (AhR) 激动剂,Kd值为70 pM。
    • HY-104026
      L-Kynurenine Agonist 99.40%
      L-Kynurenine是L-色氨酸的代谢物。它是一种芳香烃受体 (aryl hydrocarbon receptor) 激动剂。
    • HY-W007355
      Skatole Activator >98.0%
      Skatole 是肠道菌群产生的物质,通过激活芳基烃受体 (aryl hydrocarbon receptors) 和 p38 调节肠上皮细胞功能。
    • HY-19317
      ITE Agonist 99.27%
      ITE 是一种有效的内源性芳香烃受体 (AhR) 激动剂,能够直接与 AHR 结合,Ki 值为 3 nM。ITE 具有免疫抑制作用。
    • HY-N0178
      Diosmin Agonist >98.0%
      Diosmin 是在各种柑橘类水果中发现的类黄酮,也是芳烃受体 (AhR) 的激动剂。
    • HY-N0170
      Indole-3-carbinol Agonist >98.0%
      Indole-3-carbinol (I3C) 是芳烃受体 (AhR) 的激动剂。
    • HY-112629
      PDM2 Antagonist 98.88%
      PDM2 是一种选择性的高亲和力芳烃受体 (AhR) 拮抗剂,Ki 为 1.2±0.4 nM。
    • HY-109044
      Tapinarof Agonist 99.74%
      Tapinarof 是一种天然的芳烃受体 (AhR) 激动剂,EC50 为 13 nM。
    • HY-112627
      CAY 10465 Agonist 98.48%
      CAY 10465 是一种选择性的,高亲和性的芳香烃受体 (AhR) 激动剂,Ki 值为 0.2 nM,对雌激素受体 (estrogen receptor) 无作用 (Ki >100000 nM)。
    • HY-111441
      1,4-Chrysenequinone Activator
      1,4-Chrysenequinone (Chrysene-1,4-dione) 是一种多环芳香烃类,可以作为芳香烃受体 (AhR) 的激活剂起作用。
    • HY-100242
      Mivotilate Activator >98.0%
      Mivotilate 是一种非毒性的,有效的芳烃受体 (aryl hydrocarbon receptor) 激动剂,具有护肝作用。
    Isoform Specific Products

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