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    1. Cell Cycle/DNA Damage
    2. Aurora Kinase

    Aurora Kinase

    Aurora kinases are serine/threonine kinases that are essential for cell proliferation. Aurora kinase helps the dividing cell dispense its genetic materials to its daughter cells. More specifically, Aurora kinases play a crucial role in cellular division by controlling chromatid segregation. Defects in this segregation can cause genetic instability, a condition which is highly associated with tumorigenesis. Three Aurora kinases have been identified in mammalian cells to date, Aurora A, Aurora B, Aurora C. Besides being implicated as mitotic regulators, these three kinases have generated significant interest in the cancer research field due to their elevated expression profiles in many human cancers. The human Aurora kinases present a similar domain organization, with a N-terminal domain of 39 to 129 residues in length, a protein kinase domain and a short C-terminal domain containing 15 to 20 residues. The N-terminal domain of three proteins share low sequence conservation, which determines selectivity during protein-protein interactions.

    Aurora Kinase Isoform Specific Products:

    • Aurora A

    • Aurora B

    • Aurora C

    Aurora Kinase 相关产品 (36):

    Cat. No. Product Name Effect Purity
    • HY-10971
      Alisertib Inhibitor 99.43%
      Alisertib (MLN 8237)是选择性的 Aurora A 激酶抑制剂,IC50为1.2 nM。
    • HY-10161
      Tozasertib Inhibitor 99.85%
      Tozasertib 是 Aurora A/B/C 激酶抑制剂,Ki 值分别为 0.6,18,4.6 nM。
    • HY-50514
      AT9283 Inhibitor 99.13%
      AT9283是一种多靶点激酶抑制剂,有效抑制极光激酶A/BJAK2/3 (IC50=1.2 nM, 1.1 nM)。
    • HY-10126
      Barasertib-HQPA Inhibitor 99.64%
      AZD1152-HQPA是一种高度选择性的极光激酶B抑制剂,在非细胞试验中 IC50 值为0.37 nM。AZD1152-HQPA对Aurora B 的选择性是Aurora A的3700倍。
    • HY-10179
      Danusertib Inhibitor 99.44%
      Danusertib 是一种极光激酶 (aurora kinase) 抑制剂,能够抑制 Aurora A,Aurora B 和 Aurora C 的活性,IC50 值分别为 13,79 和 61 nM。
    • HY-114258
      LY3295668 Inhibitor 98.00%
      LY3295668 是高度特异性的激光激酶 A (AurA) 的抑制剂,其对 AurA 和 AurB 的Ki 值分别为 0.8 nM 和 1038 nM。
    • HY-111506
      Aurora inhibitor 1 Inhibitor
      Aurora inhibitor 1 是一种有效的 Aurora 抑制剂,抑制 Aurora AAurora B 激酶的 IC50 分别 ≤4 nM 和 ≤13 nM。
    • HY-10127
      AZD1152 Inhibitor 98.95%
      AZD1152 是 Barasertib-hQPA 的前体药物,是高度选择性的 Aurora B 抑制剂,IC50 值为 0.37 nM。
    • HY-70044
      GSK-1070916 Inhibitor 99.55%
      GSK-1070916是有效,选择性,ATP竞争型的极光激酶B/C (aurora B/C) 抑制剂,Ki 值分别为0.38和1.5 nM。
    • HY-14711
      Reversine Inhibitor 99.25%
      Reversine 是一种ATP-竞争性的 Aurora kinase 抑制剂,作用于 Aurora AAurora BAurora CIC50 分别为 400,500 和 400 nM。
    • HY-10180
      MLN8054 Inhibitor >98.0%
      MLN8054是高效,选择性,有口服活性的极光激酶 (aurora A) 抑制剂,IC50 值为4 nM。
    • HY-12054
      Hesperadin Inhibitor 98.48%
      Hesperadin是ATP竞争型的极光激酶 (aurora B) 抑制剂,IC50值为250 nM。
    • HY-10329
      JNJ-7706621 Inhibitor 98.80%
      JNJ-7706621 是一种有效的 aurora kinase 抑制剂,同时能有效抑制 CDK1CDK2,对 CDK1,CDK2,Aurora-A 和 Aurora-B 的 IC50 值分别为 9,3,11 和 15 nM。
    • HY-15767
      TAK-632 Inhibitor 99.13%
      TAK-632 是一种有效的 pan-RAF 抑制剂,作用于 CRAFBRAFV600EBRAFWTIC50 分别为 1.4,2.4 和 8.3 nM。
    • HY-14574
      PF-03814735 Inhibitor 99.77%
      PF-03814735是有效,有口服性,可逆的极光激酶A和B (aurora A/B) 的抑制剂,IC50值分别为0.8和5 nM。
    • HY-10339
      KW-2449 Inhibitor 99.85%
      KW-2449是多靶点激酶抑制剂,对FLT3ABLABLT315IAurora kinaseIC50 值分别为6.6,14,4 和 48 nM.
    • HY-13253
      AMG 900 Inhibitor 98.19%
      AMG 900 是一种有效的选择性的 pan-Aurora 激酶抑制剂,作用于 Aurora ABCIC50 分别为 5 nM,4 nM 和 1 nM。
    • HY-12201
      TAK-901 Inhibitor 99.80%
      TAK-901是多靶点的的极光激酶 (aurora)抑制剂,对极光激酶A和B的IC50 值分别为21 和15 nM。
    • HY-13252
      MK-5108 Inhibitor 98.62%
      MK-5108是高效和特异性的极光激酶A抑制剂,IC50 值为0.064 nM。
    • HY-12003
      SNS-314 Inhibitor 99.81%
      SNS-314有效,选择性的极光激酶 (aurora) 抑制剂,对极光激酶A,B,C的IC50 值分别为9,31 和6 nM。
    Isoform Specific Products

    Your Search Returned No Results.

    Sorry. There is currently no product that acts on isoform together.

    Please try each isoform separately.