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    1. Membrane Transporter/Ion Channel
    2. BCRP

    BCRP

    BCRP(breast cancer resistant protein) is an ATP-binding cassette (ABC) transporter, which together with two other ABC efflux drug pumps, namely P-glycoprotein (P-gp, ABCB1) and multidrug resistance-related protein 1 (MRP1, ABCC1) is the most important multidrug resistance protein found in eukaryotic cells including cells in the testis.

    Breast cancer resistance protein (BCRP/ABCG2) is known to localize at the blood-brain barrier (BBB) and can significantly restrict xenobiotic permeability in the brain. The objective of this study is to investigate the regulation of BCRP functional expression by peroxisome proliferator-activated receptor alpha (PPARα), a ligand-activated transcription factor primarily involved in lipid metabolism, in a cerebral microvascular endothelial cell culture system (hCMEC/D3), representative of human BBB.

    BCRP 相关产品 (9):

    Cat. No. Product Name Effect Purity
    • HY-10010
      Ko 143 Inhibitor 99.79%
      Ko 143是有效且选择性的ATP结合盒亚家族G成员2 (ABCG2) 抑制剂。
    • HY-50879
      Elacridar Inhibitor 98.47%
      Elacridar 是一种有效的 P-糖蛋白 (P-glycoprotein) 和 BCRP 的抑制剂。
    • HY-N2143
      Fumitremorgin C Inhibitor 99.63%
      Fumitremorgin C是有效,选择性的ABCG2/BRCP抑制剂。
    • HY-19753
      KS176 Inhibitor 99.21%
      KS176是一种选择性的高活性乳腺癌耐药蛋白多药转运通道 (BCRP) 抑制剂(在Pheo A和Hoechst检测中IC50值分别为0.59和1.39 μM)。对P-gp和MRP1没有抑制活性。
    • HY-12757
      YHO-13177 Inhibitor 98.40%
      YHO-13177是高活性乳腺癌耐药蛋白多药转运通道(BCRP)抑制剂,可增强SN-38活性且对P-gp无作用。
    • HY-12758
      YHO-13351 Inhibitor
      YHO-13351是YHO-13177的水溶性前体药物,YHO-13177是腺癌耐药蛋白多药转运通道(BCRP)高效特异性抑制剂。
    • HY-12758A
      YHO-13351 free base Inhibitor 98.10%
      YHO-13351 (free base) 是YHO-13177的水溶性前体药物,YHO-13177是腺癌耐药蛋白多药转运通道(BCRP)高效特异性抑制剂。
    • HY-100390
      BCRP-IN-1 Inhibitor 98.13%
      BCRP-IN-1 是一种乳腺癌抗性蛋白 (BCRP) 抑制剂,抑制 BCRP 外排转运蛋白上,IC50 为 0.6 μM。
    • HY-106004
      Zamicastat Inhibitor
      Zamicastat (BIA 5-1058) 是 多巴胺 β-羟化酶 (DBH)的抑制剂,可通过血脑屏障引起中枢和周边效应。Zamicastat 也是一种浓度依赖性的双重 P-gpBCRP 抑制剂,IC50 值分别为 73.8 μM 和 17.0 μM。具有降血压作用。
    Isoform Specific Products

    Your Search Returned No Results.

    Sorry. There is currently no product that acts on isoform together.

    Please try each isoform separately.

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