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    1. GPCR/G Protein
    2. Bombesin Receptor

    Bombesin Receptor

    Bombesin, a peptide of 14 amino acids, is an amphibian homolog to the mammalian gastrin-releasing peptide (GRP), that has been extensively studied as a targeting ligand for diagnosis and therapy of GRP positive tumors, such as breast, pancreas, lungs and prostate cancers. Bombesin binds to and activates G-protein coupled receptors, known as gastrin releasing peptide receptor (GRPR).

    Bombesin, a tetradecapeptide isolated from the skin of the frog Bombina bombina, have shown broad spectrum of biological activities. The BBS activates three G protein-coupled receptors: bombesin receptor 1 (BB1), bombesin receptor 2 (BB2), and bombesin receptor 3 (BB3). BBS-like peptides-Neuromedin B (NB) and gastrin releasing peptide (GRP) are natural ligand of the BB1 and BB2 receptors, respectively.

    In mammals, BBS receptors and BBS-like peptides are distributed in the Central Nervous System (CNS) including regions involved in the cardiorespiratory control.

    The mammalian bombesin G-protein-coupled receptor subfamily comprises three structurally related members, the receptors for neuromedin B (NMBR or BB1), gastrin-releasing peptide (GRPR or BB2), and bombesin receptor subtype-3 (BRS-3 or BB3).

    Bombesin receptor subtype-3 (BRS-3) is an orphan G protein-coupled receptor implicated in the regulation of energy homeostasis.

    Bombesin Receptor 相关产品 (4):

    Cat. No. Product Name Effect Purity
    • HY-14342
      MK-5046 Agonist 99.67%
      MK-5046是新型 BRS-3激动剂, 高亲和力与BRS-3结合 (鼠 Ki = 1.6 nM, 人 Ki = 25 nM)。
    • HY-P0195
      Bombesin 99.69%
      Bombesin是一种最初从青蛙皮肤中分离的十四肽; 在胃泌素释放和G蛋白受体活化中起重要作用。
    • HY-103286
      PD176252 Antagonist >99.0%
      PD176252 是一种有效的 BB1BB2 拮抗剂,能够抑制人 BB1 和 BB2 受体和大鼠 BB1 和 BB2 受体活性,Ki 值分别为 0.17 nM,1 nM 和 0.66 nM,16 nM;PD176252 同时为 FPR1/FPR2 的激动剂,在 HL-60 细胞中,EC<
    • HY-101844
      ML-18 Antagonist 98.04%
      ML-18是一种抑制肺癌生长的非肽铃蟾肽受体亚型-3 (BRS-3) 拮抗剂。
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