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    1. Cell Cycle/DNA Damage
    2. CDK


    CDKs (Cyclin-dependent kinases) are serine-threonine kinases first discovered for their role in regulating the cell cycle. They are also involved in regulating transcription, mRNA processing, and the differentiation of nerve cells. CDKs are relatively small proteins, with molecular weights ranging from 34 to 40 kDa, and contain little more than the kinase domain. In fact, yeast cells can proliferate normally when their CDK gene has been replaced with the homologous human gene. By definition, a CDK binds a regulatory protein called a cyclin. Without cyclin, CDK has little kinase activity; only the cyclin-CDK complex is an active kinase.

    There are around 20 Cyclin-dependent kinases (CDK1-20) known till date. CDK1, 4 and 5 are involved in cell cycle, and CDK 7, 8, 9 and 11 are associated with transcription.

    CDK levels remain relatively constant throughout the cell cycle and most regulation is post-translational. Most knowledge of CDK structure and function is based on CDKs of S. pombe (Cdc2), S. cerevisia (CDC28), and vertebrates (CDC2 and CDK2). The four major mechanisms of CDK regulation are cyclin binding, CAK phosphorylation, regulatory inhibitory phosphorylation, and binding of CDK inhibitory subunits (CKIs).

    CDK Isoform Specific Products:

    • CDK1

    • CDK2

    • CDK3

    • CDK4

    • CDK5

    • CDK6

    • CDK7

    • CDK8

    • CDK9

    • CDK12

    • CDK13

    • CDK14

    • CDK16

    • CDK19

    • CDC

    • CLK

    CDK 相关产品 (111):

    Cat. No. Product Name Effect Purity
    • HY-50767
      Palbociclib Inhibitor 99.94%
      Palbociclib (PD 0332991) 是选择性的 CDK4CDK6 抑制剂,IC50 分别为11 nM,16 nM。 Palbociclib是一种治疗ER阳性和HER2阴性乳腺癌的药物。
    • HY-16297
      Abemaciclib methanesulfonate Inhibitor 99.95%
      Abemaciclib methanesulfonate (LY2835219 methanesulfonate) 是选择性的 CDK4/6 抑制剂,抑制 CDK4/CDK6 的 IC50 分别为 2 nM 和 10 nM。
    • HY-50767A
      Palbociclib hydrochloride Inhibitor 99.94%
      Palbociclib hydrochloride是高选择性的 CDK4/6 抑制剂,IC50 分别为11 nM 和 16 nM。
    • HY-15777
      Ribociclib Inhibitor 99.85%
      Ribociclib (LEE011) 是高选择性的 CDK4/6 抑制剂,IC50 分别为10 nM,39 nM。
    • HY-10492
      Dinaciclib Inhibitor 99.73%
      Dinaciclib 是一种有效的选择性 CDK 抑制剂,抑制 CDK2CDK5CDK1CDK9IC50 分别为 1,1,3 和 4 nM。
    • HY-114177
      PF-06873600 Inhibitor 99.98%
      PF-06873600 是具有口服活性的、细胞周期蛋白依赖性激酶 (CDK) 的选择性抑制剂,其对 CDK2、CDK4 和 CDK6 的 Ki 值分别为 0.09 nM、0.13 nM 和 0.16 nM. PF-06873600 具有潜在的抗肿瘤活性。
    • HY-111388A
      SEL120-34A monohydrochloride Inhibitor 99.98%
      SEL120-34A monohydrochloride 是一种选择性的,ATP-竞争性的 CDK8 抑制剂,对 CDK8/CycC 和 CDK19/CycC 复合物的 IC50 值分别为 4.4 nM 和 10.4 nM,对 CDK8 的 Kd 值为 3 nM。SEL120-34A monohydrochloride 对 CDK9 的作用很弱,计算的 IC50 值为 1070 nM,
    • HY-119940
      (rel)-MC180295 Inhibitor
      (rel)-MC180295 是一种有效、选择性的 CDK9-Cyclin T1 抑制剂,IC50 值为 5 nM,对其选择性至少是对其他 CDK 激酶 22 倍。(rel)-MC180295 同时抑制 GSK-3α 和 GSK-3β。(rel)-MC180295 具有的抗肿瘤活性。
    • HY-103618
      THZ531 Inhibitor 99.86%
      THZ531 是 CDK12CDK13 的共价抑制剂,其 IC50 值分别为 158 nM 和 69 nM。
    • HY-80013
      THZ1 Inhibitor 98.82%
      THZ1 是有效,选择性的共价 CDK7 抑制剂,IC50 为 3.2 nM。
    • HY-30237
      Seliciclib Inhibitor 99.94%
      Seliciclib (Roscovitine) 是有效,选择性的 CDKs 抑制剂,抑制 CDK5CDK2CDK2IC50 分别为0.2 μM,0.65 μM,0.7 μM。
    • HY-A0065
      Palbociclib isethionate Inhibitor 99.99%
      Palbociclib isethionate是高选择性的 CDK4/6 抑制剂,IC50 为11 nM/16 nM。
    • HY-12529
      Ro-3306 Inhibitor
      Ro-3306 是一种有效,选择性的 CDK1 抑制剂,对 CDK1,CDK1/cyclin B1 和 CDK2/cyclin E 的 Ki 值为分别为 20 nM,35 nM 和 340 nM。
    • HY-10005
      Flavopiridol Inhibitor 99.70%
      Flavopiridol 是一种竞争型的 CDK 广谱抑制剂, 抑制 CDK1,CDK2,CDK4的IC50 分别为30,170,100 nM。
    • HY-12214A
      NVP-2 Inhibitor 99.29%
      NVP-2 是一种 CDK9 抑制剂,其 IC50 值为 0.5 nM。
    • HY-80013A
      THZ1 Hydrochloride Inhibitor 98.70%
      THZ1 Hydrochloride 是一种有效,选择性的 CDK7 抑制剂,IC50 值为 3.2 nM。
    • HY-12871
      Atuveciclib Racemate Inhibitor 98.48%
      Atuveciclib Racemate (BAY-1143572 Racemate) 是 Atuveciclib 的外消旋混合物。 Atuveciclib 是一种有效且高选择性的口服 P-TEFb/CDK9 抑制剂,CDK9/CycT1IC50 为13 nM。
    • HY-101212
      CYC065 Inhibitor 98.58%
      CYC065 是第二代口服有效的 ATP 竞争性的 CDK2 / CDK9 激酶抑制剂。
    • HY-15166
      SB1317 Inhibitor 99.96%
      SB1317 是一种有效的 CDK2JAK2FLT3 抑制剂,IC50 分别为 13,73 和 56 nM。
    • HY-12302
      Kenpaullone Inhibitor 98.07%
      Kenpaullone 是一种有效的 CDK1/cyclin BGSK-3β 抑制剂,IC50 值分别为 0.4 μM 和 23 nM,同时可抑制 CDK2/cyclin A,CDK2/cyclin E 和 CDK5/p25 的活性,IC50 值分别为 0.68 μM,7.5 μM 和 0.85 μM。
    Isoform Specific Products

    Your Search Returned No Results.

    Sorry. There is currently no product that acts on isoform together.

    Please try each isoform separately.