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    1. Metabolic Enzyme/Protease
      Neuronal Signaling
    2. COMT


    Catechol O-methyltransferase (COMT) is a ubiquitous bisubstrate magnesium-dependent enzyme found in plants, animals and microorganisms. COMT catalyses the transfer of a methyl group from S-adenosyl-L-methionine (SAM) to one of the hydroxyl oxygen atoms (preferentially the 3-hydroxyl) in a catechol substrate. Physiological substrates of COMT are catecholamine neurotransmitters such as dopamine, noradrenaline, adrenaline and their metabolites. COMT also methylates catecholic steroids such as 2-hydroxyestradiol as well as a range of other catecholic compounds including neuroactive drugs such as L-dopa, α-methyldopa and isoproterenol. COMT inhibition is a means of treating Parkinson’s disease, schizophrenia and depression. There are two isoforms of human COMT: soluble cytoplasmic COMT (S-COMT), which is mainly intracellular, and a membrane-bound form (MB-COMT), which has a single-span helix contained within a 50 amino acid extension at the N-terminus.

    COMT is an enzyme that plays a major role in catechol neurotransmitter deactivation. Inhibition of COMT can increase neurotransmitter levels, which provides a means of treatment for Parkinson’s disease, schizophrenia and depression.

    COMT 相关产品 (6):

    Cat. No. Product Name Effect Purity
    • HY-B1473
      Serotonin hydrochloride Inhibitor 99.97%
      Serotonin hydrochloride 是 CNS 中的单胺神经递质和内源性 5-HT 受体激动剂。Serotonin hydrochloride 也是儿茶酚 O-甲基转移酶 (COMT) 的抑制剂其 Ki 值为 44 μM。
    • HY-14280
      Entacapone Inhibitor 99.97%
      Entacapone是特异的外周活性的邻苯二酚-O-甲基转移酶(COMT)抑制剂,IC50为151 nM。
    • HY-17406
      Tolcapone Inhibitor 99.52%
      Tolcapone(Ro 40-7592)是口服活性的外周和中枢COMT抑制剂。
    • HY-14896
      Opicapone Inhibitor 98.80%
      Opicapone 是一种有效的儿茶酚-O-甲基转移酶e (COMT)抑制剂。Opicapone 降低细胞ATP含量,IC50为 98 μM。
    • HY-100562
      Flopropione Inhibitor 98.37%
      Flopropione 是 5-HT1A 受体拮抗剂,也是儿茶酚-O-甲基转移酶 (COMT) 的抑制剂。
    • HY-14280A
      Entacapone sodium salt Inhibitor
      Entacapone是特异的儿茶酚-o-甲基转移酶(COMT)抑制剂,IC50为151 nM。
    Isoform Specific Products

    Your Search Returned No Results.

    Sorry. There is currently no product that acts on isoform together.

    Please try each isoform separately.