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    1. Metabolic Enzyme/Protease
    2. Cathepsin


    Cathepsins are proteases (enzymes that degrades proteins) found in all animals as well as other organisms. The cathepsin family of proteolytic enzymes contains several diverse classes of proteases. Most of the members become activated at the low pH found in lysosomes. The activity of this family lies almost entirely within those organelles. Cathepsins have a vital role in mammalian cellular turnover, e.g. bone resorption. They degrade polypeptides and are distinguished by their substratespecificities. Classification: Cathepsin A, Cathepsin B, Cathepsin C, Cathepsin D, Cathepsin E, Cathepsin F, Cathepsin G, Cathepsin H, Cathepsin K, Cathepsin L1, Cathepsin L2, Cathepsin O, Cathepsin S, Cathepsin W, Cathepsin Z. Most cathepsins are lysosomal and each is involved in cellular metabolism, participating in various events such as peptide biosynthesis and protein degradation. Cathepsins may also cleave some protein precursors, thereby releasing regulatory peptides.

    Cathepsin 相关产品 (22):

    Cat. No. Product Name Effect Purity
    • HY-18234A
      Leupeptin hemisulfate Inhibitor >98.0%
      Leupeptin hemisulfate是一种可逆的,竞争性的丝氨酸/半胱氨酸蛋白酶抑制剂。
    • HY-100229
      Aloxistatin Inhibitor 98.22%
      Aloxistatin (E64d) 是可渗透细胞,不可逆的广谱半胱氨酸蛋白酶 (cysteine protease) 抑制剂。
    • HY-B0496
      PMSF Inhibitor >99.0%
    • HY-15282
      E-64 Inhibitor 99.62%
      E-64 是一种有效的不可逆的半胱氨酸蛋白酶 (cysteine proteases) 抑制剂,抑制 papainIC50 为 9 nM。
    • HY-100350
      CA-074 methyl ester Inhibitor 98.40%
      CA-074 methyl ester 是一种特异性的 Cathepsin B 抑制剂,具有保护神经,抗癌、抗炎等多种生物活性。
    • HY-P1645
      Papain 是肽酶 C1 家族中的一种半胱氨酸蛋白酶,广泛应用于食品、医药、纺织、化妆品等。
    • HY-109069
      Petesicatib Inhibitor
      Petesicatib 是一种 cathepsin S 抑制剂,可用于免疫疾病研究。
    • HY-125169
      NSC 185058 Inhibitor
      NSC 185058 是一种 ATG4B 抑制剂。ATG4B 是一种主要的半胱氨酸蛋白酶 (cysteine protease)。NSC185058 显著减弱自噬 (autophagic) 活性。
    • HY-15533
      LY 3000328 Inhibitor 99.35%
      LY 3000328 是一种有效,选择性的 Cathepsin S (Cat S) 抑制剂,抑制人和小鼠Cat S的 IC50 分别为7.7,1.67 nM。
    • HY-10042
      Odanacatib Inhibitor 99.80%
      Odanacatib (MK-0822) 是有效,选择性的组织蛋白酶K抑制剂,IC50 分别为0.2 nM 和 1 nM。
    • HY-103350
      CA-074 Inhibitor 99.85%
      CA-074是组织蛋白酶B (cathepsin B) 的有效抑制剂, Ki 值为2 to 5 nM。
    • HY-15958
      VBY-825 Inhibitor
      VBY-825是cathepsin新型可逆抑制剂,对cathepsin B, L, S和V都具有很高的抑制力。
    • HY-15100
      Balicatib Inhibitor
    • HY-17541
      Cysteine Protease inhibitor Inhibitor
      Cysteine Protease inhibitor是半胱氨酸蛋白酶(cysteine protease)抑制剂。
    • HY-17541A
      Cysteine Protease inhibitor hydrochloride Inhibitor
      Cysteine Protease inhibitor hydrochloride是半胱氨酸蛋白酶(cysteine protease)抑制剂。
    • HY-50887
      L-873724 Inhibitor
      L-873724 是一种有效、可口服、选择性、可逆的非碱性 cathepsin K 抑制剂,对 cathepsin K,cathepsin S,cathepsin L,cathepsin B 的 IC50 值分别为 0.2,178,264 和 5239 nM。L-873724 抑制兔子 cathepsin K 的活性,IC50 值为 0.5 nM,同时可抑制骨再吸收
    • HY-100223
      Calpeptin Inhibitor >98.0%
      Calpeptin 是一种有效的、具有细胞穿透性的 calpain 抑制剂,其对人血小板 Calpain I 的ID50 值为40 nM。Calpeptin 也是cathepsin K 的抑制剂。
    • HY-100227
      E 64c Inhibitor
      E 64c 是半胱氨酸蛋白酶 (cysteine proteases) 天然环氧化物抑制剂的衍生物,也是钙离子激活中性蛋白酶 (CANP) 的抑制剂和组织蛋白酶C (cathepsin C) 的弱不可逆抑制剂。
    • HY-112583
      MIV-247 Inhibitor
      MIV-247是选择性的组织蛋白酶S (cathepsin S) 抑制剂,对人,小鼠和食蟹猴组织蛋白酶S的 Ki 值分别为2.1,4.2和7.5 nM。
    • HY-111808
      BDA-410 Inhibitor
      BDA-410是一种具有抗疟疾作用的半胱氨酸蛋白酶(cysteine protease)抑制剂,BDA-410抑制疟原虫生长的IC50值为173 nM。
    Isoform Specific Products

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    Please try each isoform separately.