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    1. Membrane Transporter/Ion Channel
    2. Chloride Channel

    Chloride Channel

    Chloride channels represent a relatively under-explored target class for drug discovery as elucidation of their identity and physiological roles has lagged behind that of many other drug targets. Chloride channels are involved in a wide range of biological functions, including epithelial fluid secretion, cell-volume regulation, neuroexcitation, smooth-muscle contraction and acidification of intracellular organelles. Mutations in several chloride channels cause human diseases, including cystic fibrosis, macular degeneration, myotonia, kidney stones, renal salt wasting and hyperekplexia. Chloride-channel modulators have potential applications in the treatment of some of these disorders, as well as in secretory diarrhoeas, polycystic kidney disease, osteoporosis and hypertension.

    Chloride channel accessory proteins, also known as calcium-activated chloride channel regulators (CLCA proteins), are a family of transmembrane proteins that have been suggested to have a role in chloride conductance in epithelial cells.

    Chloride Channel 相关产品 (13):

    Cat. No. Product Name Effect Purity
    • HY-N0822
      Shikonin Inhibitor 99.80%
      Shikonin是中草药紫草的主要成分。 Shikonin显示出各种生物活性,包括抑制TNF-αNF-κBHIV-1
    • HY-12693
      R(+)-IAA-94 Inhibitor 99.70%
    • HY-B1221
      Flufenamic acid Inhibitor 99.92%
      Flufenamic acid 是一种非甾体类抗炎剂,能够抑制 COX 的活性,激活 AMPK 的活性,调节离子通道,阻滞氯离子通道 (chloride channel) 和 L-型钙离子通道 (L-type Ca2+ channel),调节非选择性阳离子通道,激活钾离子通道 (K+ channel) 等。
    • HY-B0679
      Lubiprostone Activator >98.0%
    • HY-100611
      CaCCinh-A01 Inhibitor 99.60%
      CaCCinh-A01 是 TMEM16A 和钙激活氯化物通道 (CaCC) 的抑制剂,IC50 值分别为 2.1 和 10 μM。
    • HY-101012
      NPPB Inhibitor 99.89%
      NPPB 是外向整流氯化物通道 (ORCC) 的阻断剂。
    • HY-108690
      Fluxametamide Antagonist 98.51%
      Fluxametamide 是一种广谱的杀虫剂,为 GABA-和谷氨酸门控氯离子通道 (chloride channel) 拮抗剂,对 M. domestica 中 GABACl 和 GluCl 的 IC50 值分别为 1.95 ?nM 和 225 ?nM。
    • HY-B0493
      Niflumic acid Inhibitor 99.86%
      Niflumic acid是钙离子激活的氯离子通道阻断剂,可作用于风湿性关节炎。
    • HY-18996
      Adjudin Inhibitor >98.0%
      Adjudin 是一种广泛研究的男性避孕试剂,具有优越的线粒体抑制作用。 Adjudin 也是一种有效的 Cl- 通道阻断剂。
    • HY-P0173A
      Chlorotoxin Inhibitor >98.0%
      Chlorotoxin是从雷蛇属以色列蝎子的毒液中提取的由36个氨基酸组成的肽段,具有抗癌活性。Chlorotoxin是氯离子通道 (chloride channel) 阻断剂。
    • HY-B0908
      Meticrane Inhibitor 98.79%
      Meticrane 是一种利尿剂。Meticrane 抑制远曲小管中钠离子和氯离子的重吸收。Meticrane 可于治疗原发性高血压。
    • HY-100244
      NS1652 Inhibitor
      NS1652 是一种可逆的阴离子电导 (anion conductance) 抑制剂,在人和小鼠的红细胞中,可以抑制氯离子通道 (chloride channel),IC50 值为 1.6 μM。
    • HY-100322
      H100 Inhibitor
      H100 是一种氯离子运输 (Cl- transport) 抑制剂,可以部分抑制氯离子载体 NaK2Cl cotransporter 和 Band 3 anion exchanger,但是对 KCl cotransporter 无作用。
    Isoform Specific Products

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