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    1. Protein Tyrosine Kinase/RTK
    2. Discoidin Domain Receptor

    Discoidin Domain Receptor

    Discoidin domain receptors (DDRs) are receptor tyrosine kinases with the unique ability among receptor tyrosine kinases to respond to collagen. Several signaling molecules have been implicated in DDR signaling, including Shp-2, Src, and MAPK pathways. DDRs have been reported to induce the expression of various genes including matrix metalloproteinases and bone morphogenetic proteins, but the regulatory mechanisms underlying DDR-induced gene expression remain to be determined. DDRs regulate cell-collagen interactions in normal and pathological conditions and thus are emerging as major sensors of collagen matrices and potential novel therapeutic targets.

    Discoidin Domain Receptor 相关产品 (5):

    Cat. No. Product Name Effect Purity
    • HY-16961
      Sitravatinib Inhibitor 99.85%
      Sitravatinib (MGCD516; MG516) 是一种有口服活性的受体酪氨酸激酶 (RTK) 抑制剂。抑制 Axl,MER,VEGFR3,VEGFR2,VEGFR1,KIT,FLT3,DDR2,DDR1,TRKA,和 TRKB,IC50 分别为 1.5 nM,2 nM,2 nM,5 nM,6nM,6 nM,8 nM,0.5 nM,29 nM,5nM,和 9 nM。
    • HY-13979
      DDR1-IN-1 Inhibitor >98.0%
      DDR1-IN-1是DDR1受体酪氨酸激酶抑制剂,IC50和EC50分别为105 nM和87 nM,而对DDR2的IC50为413 nM。
    • HY-U00444
      DDR1-IN-2 Inhibitor >98.0%
      DDR1-IN-2 是一种盘状结构域受体 1 (DDR1) 抑制剂,IC50 值为 13.1 nM,对 DDR2 的抑制作用相对较弱,IC50 of 203 nM。
    • HY-W018931
      DDR Inhibitor Inhibitor
      DDR Inhibitor 是一种高效的盘状结构域受体 (discoidin domain receptor) 抑制剂,对 DDR2 的 IC50 值为 3.3 nM,在浓度为 1.5 nM 时,对 DDR1 有 53% 的抑制作用。
    • HY-100695
      DDR1-IN-3 Inhibitor
      DDR1-IN-3 是圆盘状受体 1 (DDR1) 的一个选择性抑制剂,其 IC50 值为 9.4 nM。
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