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    1. GPCR/G Protein
    2. EBI2/GPR183

    EBI2/GPR183

    The Epstein-Barr virus (EBV) induced receptor 2 (EBI2; also known as GPR183) is an orphan member of the 7TM receptor family A. EBI2 is a constitutively active seven-transmembrane receptor. EBI2 has been placed in varying 7TM receptor subgroups by different phylogenetic analyses as being a target of peptide or lipid ligands. EBI2 constitutively activates extracellular signal-regulated kinase (ERK) in a pertussis toxin-insensitive manner. EBI2 is up-regulated up to 200-fold in B cells following EBV infection.

    EBI2 activation stimulates immune cell migration and has been genetically linked to autoimmune diseases including type 1 diabetes. Small molecule modulators of EBI2 can be useful for probing the function of the receptor and its relevance to human diseases.

    EBI2/GPR183 相关产品 (2):

    Cat. No. Product Name Effect Purity
    • HY-101192
      GSK682753A Inhibitor 98.47%
      GSK682753A是EB病毒诱导受体2 (EBI2) 的反向激动剂, IC50值为 53.6 nM。
    • HY-12336
      NIBR189 Antagonist 99.24%
      NIBR189是一个EBI2(GPR183)小分子拮抗剂,IC50值为11nM。
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