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    1. Immunology/Inflammation
    2. FLAP


    FLAP (Arachidonate 5-lipoxygenase-activating protein) is a protein that in humans is encoded by the ALOX5AP gene. FLAP is necessary for the activation of 5-lipoxygenase and therefore for the production of leukotrienes. It is an integral protein within the nuclear membrane. FLAP is necessary in synthesis of leukotriene, which are lipid mediators of inflammation that is involved in respiratory and cardiovascular diseases. FLAP functions as a membrane anchor for 5-lipooxygenase and as an amine acid-bind protein. Gene polymorphisms in FLAP are suspected of playing a role in Alzheimer's disease. Leukotrienes, which need the FLAP protein to be made, have an established pathological role in allergic and respiratory diseases. Animal and human genetic evidence suggests they may also have an important role in atherosclerosis, myocardial infarction, and stroke. The structure of FLAP provides a tool for the development of novel therapies for respiratory and cardiovascular diseases and for the design of focused experiments to probe the cell biology of FLAP and its role in leukotriene biosynthesis.

    FLAP 相关产品 (7):

    Cat. No. Product Name Effect Purity
    • HY-14166
      MK-886 Inhibitor 99.77%
      MK886是<5>脂氧合酶活化蛋白抑制剂和白三烯生物合成抑制剂 (IC50=2.5 nM)。
    • HY-15874
      Fiboflapon Inhibitor 98.18%
      Fiboflapon (GSK2190915) 是 FLAP 高效选择性抑制剂,binding IC50值为 2.9 nM。
    • HY-15874A
      Fiboflapon sodium Inhibitor 99.08%
      Fiboflapon sodium (GSK2190915 (sodium salt)) 是 FLAP 高效选择性抑制剂,binding IC50值为 2.9 nM。
    • HY-50714
      Quiflapon sodium Inhibitor 99.25%
      Quiflapon sodium (MK591) 是选择性的,特异性的 FLAP 抑制剂。
    • HY-10037
      MK591 free acid Inhibitor
      MK591 (free acid) 是FLAP特异性抑制剂,IC50 为1.6 nM。
    • HY-14460
      AM679 Inhibitor 99.98%
      AM679是高活性FLAP抑制剂,对FLAP结合/hLA/hWB的IC50分别为2.2 nM/0.6 nM/154 nM。
    • HY-14163
      AM 103 Inhibitor
      AM 103 是具有选择性的,有效的 FLAP 抑制剂,IC50 值为 4.2 nM。
    Isoform Specific Products

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