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    1. GPCR/G Protein
    2. GNRH Receptor

    GNRH Receptor

    GNRH Receptor (Gonadotropin-releasing hormone receptor, GNRHR), also known as the luteinizing hormone releasing hormone receptor (LHRHR), is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes,breast, ovary, and prostate. GNRH Receptor is a 60 kDa G protein-coupled receptor and resides primarily in the pituitary and is responsible for eliciting the actions of LHRH after its release from the hypothalamus. Upon activation, GNRH Receptor stimulates tyrosine phosphatase and elicits the release of LH from the pituitary. Following binding of Gonadotropin releasing hormone (GNRH), GNRH Receptor associates with G-proteins that activate a phosphatidylinositol (PtdIns)-calcium second messenger system. Activation of GNRHR ultimately causes the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH).

    GNRH Receptor 相关产品 (19):

    Cat. No. Product Name Effect Purity
    • HY-16168A
      Degarelix Antagonist 99.92%
      Degarelix是一种竞争性,可逆的的促性腺激素释放激素受体 (GnRHR) 拮抗剂。
    • HY-13665
      Leuprolide Acetate Agonist 99.88%
      Leuprolide acetate是一种有效的促性腺激素释放激素 (GNRH)受体激动剂,用于治疗前列腺癌,子宫内膜异位症,子宫肌瘤。
    • HY-17405
      Alarelin Acetate Agonist 99.61%
      Alarelin acetate是合成的GnRH激动剂。
    • HY-12551
      Triptorelin Agonist 98.44%
    • HY-P0009A
      Cetrorelix Acetate Antagonist 98.88%
      Cetrorelix Acetate是 GnRH 受体的强效拮抗剂,其 IC50 值为 1.21 nM.
    • HY-12551A
      Triptorelin acetate Agonist 99.88%
      Triptorelin acetate 是促性腺激素释放激素 (GnRH) 受体激动剂。
    • HY-13534
      Abarelix Antagonist 98.11%
      Abarelix 是有效的促性腺激素释放激素 (GnRH) 拮抗剂,用于治疗前列腺癌。
    • HY-12556
      Deslorelin Agonist 99.78%
    • HY-13673A
      Goserelin acetate Agonist 99.96%
      Goserelin (ICI 118630)乙酸盐是GnRH激动剂。
    • HY-13581A
      Buserelin Acetate Agonist 99.98%
      Buserelin (INN) Acetate是一个GnRH的激动剂。
    • HY-14789
      Elagolix Antagonist 98.06%
      Elagolix是一种高度有效的, 选择性, 口服活性的, 短期的, 非肽类促性腺激素释放激素受体 (GnRH受体) 拮抗剂 (KD = 54 pM)。
    • HY-14369
      Elagolix sodium Antagonist 99.20%
      Elagolix sodium 是一种人的 GnRH 受体 (GnRHR) 拮抗剂,其 IC50Ki 值分别为 0.25 和 3.7 nM。
    • HY-16474
      Relugolix Antagonist >98.0%
      Relugolix是一个新颖的,非肽的能够口服的GnRH拮抗剂,IC50值是0.33 nM.
    • HY-12555
      Gonadorelin acetate Agonist 99.97%
    • HY-P0051
      Lecirelin Agonist
      Lecirelin 是 GnRH 的合成类似物,可用于治疗牛卵巢滤泡囊肿。
    • HY-P0057
      Nafarelin Agonist 98.99%
      Nafarelin 是促性腺激素释放激素 (GnRH) 的激动剂,它能促进促黄体激素 (LH) 和促卵泡激素 (FSH) 的分泌。
    • HY-13673
      Goserelin Agonist
      Goserelin(ICI 118630)是注射型促性腺激素释放激素(GnRH)超激动剂。
    • HY-12553
      Leuprorelin Agonist
    • HY-U00289
      opigolix Antagonist
      Opigolix 是一种促性腺激素释放激素 (GnRH) 受体拮抗剂,可用于子宫内膜异位症和风湿性关节炎等疾病的研究。
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