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    1. GPCR/G Protein
    2. GPR119


    GPR119 (G protein-coupled receptor 119) is a G protein-coupled receptor that in humans is encoded by the GPR119 gene. GPR119, along with GPR55 and GPR18, have been implicated as novel cannabinoid receptors. GPR119 is expressed predominantly in the pancreas and gastrointestinal tract in rodents and humans, as well as in the brain in rodents. Activation of the receptor has been shown to cause a reduction in food intake and body weight gain in rats. GPR119 has also been shown to regulate incretin and insulin hormone secretion. As a result, new drugs acting on the receptor have been suggested as novel treatments forobesity and diabetes.

    GPR119 相关产品 (7):

    Cat. No. Product Name Effect Purity
    • HY-15564
      AR 231453 Agonist 99.52%
      AR231453是一种有效,选择性和可口服的 GPR119 激动剂。
    • HY-15566
      APD597 Agonist 99.97%
      APD597是GPR119激动剂, 作用于hGPR119, EC50为46 nM, 可用于治疗2型糖尿病。
    • HY-15291
      MBX-2982 Agonist 99.39%
      MBX-2982 是一种口服选择性的 G 蛋白偶联受体 119 (GPR119) 激动剂。
    • HY-12066
      GSK1292263 Agonist 98.77%
    • HY-16673
      PSN632408 Agonist 99.91%
      PSN632408是GPR119受体激动剂,与内源性配体OEA活性接近,对重组型鼠和人的GPR119受体的EC50分别为5.6和7.9 uM。
    • HY-109032
      Firuglipel Agonist
      Firuglipel (DS-8500a)是高效,选择性,有口服活性的 GPR119 激动剂。
    • HY-15565
      APD668 Agonist 99.16%
      APD668是GPR119激动剂,对人GPR119和大鼠GPR119的EC50分别为2.7 nM和33 nM。
    Isoform Specific Products

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    Please try each isoform separately.