<noframes id="zd9f3">

    <address id="zd9f3"></address>

    <address id="zd9f3"></address>
    <address id="zd9f3"></address>

    <address id="zd9f3"><nobr id="zd9f3"><meter id="zd9f3"></meter></nobr></address>
    1. GPCR/G Protein
    2. Glucocorticoid Receptor

    Glucocorticoid Receptor

    Glucocorticoid Receptor (GR, or GCR) also known as NR3C1 (nuclear receptor subfamily 3, group C, member 1) is the receptor to which cortisol and other glucocorticoids bind. The GR is expressed in almost every cell in the body and regulates genes controlling the development, metabolism, and immune response. When the glucocorticoid receptor binds to glucocorticoids, its primary mechanism of action is the regulation of gene transcription. The unbound receptor resides in the cytosol of the cell. After the receptor is bound to glucocorticoid, the receptor-glucorticoid complex can take either of two paths. The activated GR complex up-regulates the expression of anti-inflammatory proteins in the nucleus or represses the expression of pro-inflammatory proteins in the cytosol by preventing the translocation of other transcription factors from the cytosol into the nucleus. Dexamethasone is an agonist, and RU486 and cyproterone acetate are antagonists of the GR. Also, progesterone and DHEA have antagonist effects on the GR.

    Glucocorticoid Receptor 相关产品 (54):

    Cat. No. Product Name Effect Purity
    • HY-14648
      Dexamethasone Agonist 99.85%
      Dexamethasone 是一种糖皮质激素受体 (glucocorticoid receptor) 激动剂。
    • HY-N0583
      Hydrocortisone Agonist 99.66%
    • HY-13683
      Mifepristone Antagonist 98.17%
      Mifepristone是黄体酮受体 (PR) 和糖皮质激素受体 (GR) 拮抗剂,体外实验中的 IC50 值分别为0.2 nM 和2.6 nM。
    • HY-B1618
      Corticosterone 99.07%
    • HY-17463
      Prednisolone Agonist >98.0%
    • HY-120012
      AZD9567 Modulator >99.0%
      AZD9567 (compound 15) 是一种有效的、具有口服活性的、非甾体类的、选择性糖皮质激素受体调节剂 (SGRM), 其 IC50 值为 3.8 nM。对 SCW 联合炎症表现出良好的疗效。
    • HY-113854
      AZD2906 Agonist 99.82%
      AZD2906 为一种选择性的糖皮质激素受体 glucocorticoid receptor (GR) 激动剂,对人、大鼠 PBMC 和全血中 GR 的 IC50 值分别为 2.2,0.3,41.6 和 7.5 nM。AZD2906 能够增加大鼠骨髓中的微核未成熟红细胞。
    • HY-112710
      ORIC-101 Antagonist
      ORIC-101 是一种有效、选择性的糖皮质激素受体 (glucocorticoid receptor) 拮抗剂,EC50 值为 5.6 nM。抗癌作用。
    • HY-B1829A
      Dexamethasone phosphate disodium Agonist 99.68%
      Dexamethasone phosphate disodium is a glucocorticoid receptor agonist.
    • HY-B0214
      Prednisone Agonist 99.35%
      Prednisone (Adasone)是皮质类固醇试剂,有免疫抑制作用。
    • HY-B0260
      Methylprednisolone Agonist 99.67%
    • HY-N0835
      (20S)-Protopanaxatriol Agonist >98.0%
      (20S)-Protopanaxatriol 是人参皂苷的代谢物,通过 glucocorticoid receptoroestrogen receptor 起作用,同时为 LXRα 的抑制剂。
    • HY-13580
      Budesonide Agonist >98.0%
    • HY-14648A
      Dexamethasone acetate Agonist 99.34%
    • HY-B0328
      Triamcinolone Inhibitor 99.15%
    • HY-B0154
      Fluticasone propionate Agonist 99.57%
    • HY-14864
      Mapracorat Agonist 99.40%
      Mapracorat 是新型的非甾类有选择性的 glucocorticoid receptor 激动剂。
    • HY-14234
      Glucocorticoid receptor agonist Agonist 98.57%
      Glucocorticoid receptor agonist是Glucocorticoid受体激动剂。
    • HY-B0636
      Triamcinolone acetonide Agonist 99.08%
      Triamcinolone Acetonide的有效性是prednisone的八倍。
    • HY-17461
      Cortisone Agonist 98.63%
    Isoform Specific Products

    Your Search Returned No Results.

    Sorry. There is currently no product that acts on isoform together.

    Please try each isoform separately.