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    1. Metabolic Enzyme/Protease
    2. Glucokinase

    Glucokinase

    Glucokinase is an enzyme that facilitates phosphorylation of glucose to glucose-6-phosphate. Glucokinase occurs in cells in theliver, pancreas, gut, and brain of humans and most other vertebrates. In each of these organs it plays an important role in the regulation of carbohydrate metabolism by acting as a glucose sensor, triggering shifts in metabolism or cell function in response to rising or falling levels of glucose, such as occur after a meal or when fasting. Glucokinase has a lower affinity for glucose than the other hexokinases do, and its activity is localized to a few cell types, leaving the other three hexokinases as more important preparers of glucose for glycolysis and glycogen synthesis for most tissues and organs. Mutations of the gene for this enzyme can cause unusual forms of diabetes or hypoglycemia.

    Glucokinase 相关产品 (8):

    Cat. No. Product Name Effect Purity
    • HY-N2341
      Palmitelaidic Acid Activator >99.0%
      Palmitelaidic acid是棕榈油酸palmitoleic acid的反式异构体。 棕榈油酸是血清和组织中最丰富的脂肪酸之一。
    • HY-10595
      Ro 28-1675 Activator 99.41%
      Ro 28-1675 (Ro 0281675)是变构的GK活化剂,SC1.5为0.24 uM。
    • HY-100221
      AM-2394 Activator 98.71%
      AM-2394 是一种新型的 glucokinase 激活剂 (GKA)。AM-2394激活葡萄糖激酶 (GK),EC50 为 60 nM。
    • HY-12411
      AMG-3969 Modulator 99.63%
      AMG-3969是有效的葡萄糖激酶-葡糖激酶调节蛋白(GK-GKRP)相互作用的干扰物,IC50值为4 nM。
    • HY-13529
      LY2608204 Activator 98.18%
      LY2608204是葡萄糖激酶(GK)活化剂,EC50为42 nM。
    • HY-101788
      Glucokinase activator 1 Activator
      Glucokinase activator 1 是针对肝脏的葡萄糖激酶活化剂,EC50 为34 nM。
    • HY-100181
      PF-04991532 Activator
      PF-04991532 是一种有效的肝选择性葡萄糖激酶激活剂,在人类和大鼠中的 EC50 值分别为 80 和 100 nM。
    • HY-U00411
      PSN-GK1 Activator
      PSN-GK1是有效的葡萄糖激酶 (glucokinase) 活化剂,EC50 值为0.13 μM。
    Isoform Specific Products

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    Sorry. There is currently no product that acts on isoform together.

    Please try each isoform separately.

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