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    1. Membrane Transporter/Ion Channel
      Neuronal Signaling
    2. GlyT


    Glycine transporters (GlyTs) belong to a large family of Na+/Cl--dependent transporter proteins that includes transporters for monoamines [5-hydroxytryptamine (serotonin), noradrenaline and dopamine] and γ-aminobutyric acid. GlyT-mediated glycine uptake is energetically coupled with the transmembrane sodium gradient maintained by the Na+/K+-ATPase.

    GlyT1 is essential for regulating glycine concentrations at synaptic receptors.

    GlyT2 is uniquely designed for neurotransmitter recycling at inhibitory glycinergic synapses, and loss of GlyT2 function generates a severely hyperexcited state.

    GlyT 相关产品 (7):

    Cat. No. Product Name Effect Purity
    • HY-10809
      Bitopertin Inhibitor 99.75%
      Bitopertin 是一种有效的非竞争性glycine reuptake 抑制剂,抑制甘氨酸摄取,IC50 为 25 nM。
    • HY-100416A
      LY2365109 hydrochloride Inhibitor 98.83%
      LY2365109是一个强的和选择性的GlyT1抑制剂,IC50是15.8 nM.
    • HY-18723
      GlyT2-IN-1 Inhibitor 99.95%
      GlyT2-IN-1是甘氨酸转运体GLYT2抑制剂, 是一种新型的机械传导通道Piezo1激动剂, 作用于Piezo1-而非载体转染的细胞, 引发Ca2+外流。
    • HY-10809A
      Bitopertin R enantiomer Inhibitor
      RG1678 (Bitopertin)R型对映体是非竞争性甘氨酸重吸收(GlyT1)抑制剂。
    • HY-112432
      GlyT1 Inhibitor 1 Inhibitor
      GlyT1 Inhibitor 1 是一种有效的选择性 GlyT1 抑制剂,抑制 rGlyT1 IC50 为 38 nM。
    • HY-19887
      Tilapertin Inhibitor
      Tilapertin 是甘氨酸转运蛋白 1 型 (GlyT1) 的口服抑制剂。
    • HY-101037
      Sarcosine Inhibitor
      Sarcosine 1型甘氨酸转运蛋白 (GlyT) 抑制剂和甘氨酸结合位点的N-甲基-D-天冬氨酸 (NMDA) 受体共激动剂。
    Isoform Specific Products

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    Sorry. There is currently no product that acts on isoform together.

    Please try each isoform separately.