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    1. Membrane Transporter/Ion Channel
    2. HCN Channel

    HCN Channel

    Hyperpolarization- and Cyclic Nucleotide-gated (HCN) channels are a family of six transmembrane domain, single pore-loop, hyperpolarization activated, non-selective cation channels. The HCN family consists of four members (HCN1-4). HCN channels represent the molecular correlates of I(h), a hyperpolarization-activated current best known for its role in controlling heart rate and in the regulation of neuronal resting membrane potential and excitability.

    HCN channels are unique among vertebrate voltage-gated ion channels, in that they have a reverse voltage-dependence that leads to activation upon hyperpolarization. HCN channels are encoded by four genes (HCN1-4) and are widely expressed throughout the heart and the central nervous system.

    HCN Channel 相关产品 (4):

    Cat. No. Product Name Effect Purity
    • HY-101346
      ZD7288 Inhibitor 99.79%
      ZD7288 是一种有选择性的超极化激活的环核苷酸门控 (HCN) 通道阻断剂。
    • HY-13422A
      Zatebradine Antagonist 98.80%
      Zatebradine(UL-FS49)是HCN离子通道高效拮抗剂,可逆性降低心率,10uM浓度可抑制hHCN1达92%。
    • HY-13422
      Zatebradine hydrochloride Antagonist 99.15%
      Zatebradine(UL-FS49)盐酸盐是HCN离子通道高效拮抗剂,可逆性降低心率,10uM浓度可抑制hHCN1达92%。
    • HY-18940A
      Cilobradine hydrochloride Inhibitor
      Cilobradine是一种HCN通道阻断剂。
    Isoform Specific Products

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