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    1. Cell Cycle/DNA Damage
    2. Haspin Kinase

    Haspin Kinase

    Haspin is a protein kinase that regulates chromosome and spindle function during mitosis and meiosis. Haspin expression is detected in fetal liver, skin, kidney, small intestine and in all proliferating cells. Haspin phosphorylates H3 thr3 (H3T3ph) in human cell lines and depletion of Haspin by RNA interference reveals that Haspin is required for H3 thr3 phosphorylation in mitotic cells. Phosphorylation of H3T3ph by Haspin is necessary for chromosomal passenger complex (CPC) accumulation at centromeres. H3T3ph then positions the CPC at centromeres to regulate selected targets of Aurora B during mitosis.

    Haspin Kinase 相关产品 (2):

    Cat. No. Product Name Effect Purity
    • HY-15217
      CHR-6494 Inhibitor 98.12%
      CHR-6494 是一种有效的 haspin 抑制剂,能够抑制组蛋白 H3T3 的磷酸化,IC50 值为 2 nM。
    • HY-13455
      LDN-192960 Inhibitor 99.56%
      LDN-192960 是一种有效的 Haspin (单倍体生殖细胞特异性核蛋白激酶) 抑制剂,其 IC50 值为 0.010 μM。
    Isoform Specific Products

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