<noframes id="zd9f3">

    <address id="zd9f3"></address>

    <address id="zd9f3"></address>
    <address id="zd9f3"></address>

    <address id="zd9f3"><nobr id="zd9f3"><meter id="zd9f3"></meter></nobr></address>
    1. Cell Cycle/DNA Damage
    2. IRE1


    The serine/threonine-protein kinase/endoribonuclease inositol-requiring enzyme 1 (IRE1) is an enzyme that in humans is encoded by the ERN1 gene. IRE1 is an endoplasmic reticulum (ER) transmembrane sensor that activates UPR to maintain ER and cellular function. While mammalian IRE1 promotes cell survive, it can initiate apoptosis via decay of anti-apoptotic microRNAs.

    IRE1 activation is initiated by homotypic interactions of the stress-sensing lumenal domain favoring transautophosphorylation of the kinase-extension nuclease (KEN) domain on the cytoplasmic side of the ER membrane.

    IRE1/XBP-1 has been shown to regulate a variety of genes in various cell types in response to ER stress, mostly related to ER function and the secretory pathway, although the target genes vary depending on the cell type and nature of the stress stimuli.

    IRE1 相关产品 (13):

    Cat. No. Product Name Effect Purity
    • HY-15845
      STF-083010 Inhibitor >98.0%
      STF-083010 is an Ire1 inhibitor. STF-083010 inhibits Ire1 endonuclease activity, without affecting its kinase activity, after endoplasmic reticulum stress.
    • HY-19707
      4μ8C Inhibitor 98.52%
      4μ8C (IRE1 Inhibitor III)是IRE1α的小分子抑制剂。
    • HY-19708
      KIRA6 Inhibitor 98.75%
      KIRA6变构抑制IRE1α RNase激酶活性,IC50值为0.6 μM。
    • HY-17537
      APY29 Inhibitor 99.54%
      APY29 是一种特异性的 IRE1α 别构调节剂,能够抑制IRE1α的自主磷酸化,IC50 值为 280 nM,也可激活核糖核酸酶活性。
    • HY-19710
      MKC3946 Inhibitor 99.77%
      MKC3946 是一种有效的 IRE1α 抑制剂,常用于癌症研究。
    • HY-114368
      Kira8 Inhibitor
      Kira8 是一种单选择性 IRE1α 抑制剂,可以变构减弱 IRE1α RNase 活性,IC50 为 5.9 nM。
    • HY-107400
      B I09 Inhibitor
      B I09 是 IRE-1 核糖核酸酶的一个抑制剂,其 IC50 值为 1230 nM。
    • HY-U00459
      GSK2850163 Inhibitor >98.0%
      GSK2850163 是一个新型的肌醇需要酶-1α (IRE1α) 抑制剂,它可抑制 IRE1α 的激酶活性和 RNA 酶活性,其 IC50 值分别为 20 和 200 nM。
    • HY-104040
      MKC8866 Inhibitor 98.38%
      MKC8866 是一种肌醇需要酶 (IRE-1α) 抑制剂,IC50 小于 0.1 μM。
    • HY-12399
      MKC9989 Inhibitor 98.61%
      MKC9989 是一种 HAA 抑制剂,且能抑制 IRE1αIC50 值在 0.23 μM 至 44 μM 的范围之间。
    • HY-107371
      NSC95682 Inhibitor 99.87%
      NSC95682 是一个 IRE-1α 抑制剂,其 IC50 值为 0.08 μM,来自专利 WO 2008154484 A1, 实例 IRE-lα 抑制剂化合物 3-5。
    • HY-U00460
      3,6-DMAD hydrochloride Inhibitor >98.0%
      3,6-DMAD hydrochloride是未折叠蛋白质应答 (IRE1α-XBP1) 通路的抑制剂。
    • HY-U00459B
      GSK2850163 hydrochloride Inhibitor
      GSK2850163 hydrochloride 是一个新型的肌醇需要酶-1α (IRE1α) 抑制剂,它可抑制 IRE1α 的激酶活性和 RNA 酶活性,其 IC50 值分别为 20 和 200 nM。
    Isoform Specific Products

    Your Search Returned No Results.

    Sorry. There is currently no product that acts on isoform together.

    Please try each isoform separately.