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    1. GPCR/G Protein
      Neuronal Signaling
    2. Imidazoline Receptor

    Imidazoline Receptor

    Imidazoline receptors are the primary receptors on which clonidine and other imidazolines act. There are three classes of imidazoline receptors: I1 receptor – mediates the sympatho-inhibitory actions of imidazolines to lower blood pressure, (NISCH or IRAS, imidazoline receptor antisera selected), I2 receptor - an allosteric binding site of monoamine oxidase and is involved in pain modulation and neuroprotection, I3 receptor - regulates insulin secretion from pancreatic beta cells. Activated I1-imidazoline receptors trigger the hydrolysis of phosphatidylcholine into DAG. Elevated DAG levels in turn trigger the synthesis of second messengers arachidonic acid and downstreameicosanoids. In addition, the sodium-hydrogen antiporter is inhibited, and enzymes of catecholamine synthesis are induced. The I1-imidazoline receptor may belong to the neurocytokine receptorfamily, since its signaling pathways are similar to those of interleukins.

    Imidazoline Receptor 相关产品 (5):

    Cat. No. Product Name Effect Purity
    • HY-N0543
      Allantoin Agonist 98.36%
    • HY-101238
      Agmatine sulfate Agonist >98.0%
      Agmatine sulfate在多个靶点上发挥调节作用,如神经递质系统,离子通道,一氧化氮合成。它是 imidazoline receptor 的内源性激动剂和 NO synthase 抑制剂。
    • HY-B0374
      Moxonidine Agonist 99.91%
    • HY-B0374A
      Moxonidine hydrochloride Agonist
    • HY-100179
      CR4056 Agonist 98.32%
      CR4056 是一个选择性的人重组 MAO-A 抑制剂,其 IC50 值为 202.7 nM。 CR4056 也是咪唑啉-2 受体 (I2R) 的配体,其 IC50 值为 596 nM。
    Isoform Specific Products

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    Sorry. There is currently no product that acts on isoform together.

    Please try each isoform separately.