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    1. MAPK/ERK Pathway
    2. JNK

    JNK

    JNKs (c-Jun N-terminal kinases) belong to the mitogen-activated protein kinase family, and are responsive to stress stimuli, such as cytokines,ultraviolet irradiation, heat shock, and osmotic shock. JNKs play a role in T cell differentiation and the cellular apoptosis pathway. Activation occurs through a dual phosphorylation of threonine (Thr) and tyrosine (Tyr) residues within a Thr-Pro-Tyr motif located in kinase subdomain VIII. Activation is carried out by two MAP kinases, MKK4 and MKK7 and JNK can be inactivated by Ser/Thr and Tyr protein phosphatases. Downstream molecules that are activated by JNK include c-Jun, ATF2, ELK1, SMAD4, p53 and HSF1. JNKs can associate with scaffold proteins JNK interacting proteins as well as their upstream kinases JNKK1 and JNKK2 following their activation. JNK activity regulates several important cellular functions including cell growth, differentiation, survival and apoptosis.

    JNK Isoform Specific Products:

    • JNK1

    • JNK2

    • JNK3

    • JNK

    JNK 相关产品 (22):

    Cat. No. Product Name Effect Purity
    • HY-12041
      SP600125 Inhibitor 98.82%
      SP600125是一种可逆,ATP竞争性的 JNK 抑制剂,抑制 JNK1JNK2JNK3IC50 分别为 40, 40, 90 nM。
    • HY-13319
      JNK-IN-8 Inhibitor 99.38%
      JNK-IN-8 是一种有效的 JNK 抑制剂,抑制 JNK1JNK2JNK3IC50 分别为 4.7 nM,18.7 nM 和 1 nM。
    • HY-N2149
      Tomatidine Inhibitor >98.0%
      Tomatidine 通过阻断 NF-κBJNK 信号发挥抗炎作用。
    • HY-15495
      Tanzisertib Inhibitor 99.98%
      Tanzisertib (CC-930) 是有效的 JNK1/2/3 抑制剂,IC50 分别为61/7/6 nM。
    • HY-N0431
      Astragaloside IV Inhibitor 99.15%
      Astragaloside IV 是从黄芪中分到的皂苷类物质,能够抑制 ERK1/2JNK 的激活,在乳腺癌细胞 MDA-MB-231 中,能够下调 (MMP)-2,(MMP)-9 的信号通路。
    • HY-P0069A
      L-JNKI-1 Inhibitor
      L-JNKI-1 是一种针对 JNK 的细胞渗透性多肽抑制剂。
    • HY-N0148A
      Rutin hydrate Inhibitor
      Rutin hydrate 是一种黄酮苷类化合物,能够透过血脑屏障,通过抑制 JNKERK1/2 的活化,激活 mTOR 通路来起作用。
    • HY-P0069
      D-JNKI-1 Inhibitor
      D-JNKI-1 是高效可渗透细胞的 JNK 抑制剂。序列: Asp-Gln-Ser-Arg-Pro-Val-Gln-Pro-Phe-Leu-Asn-Leu-Thr-Thr-Pro-Arg-Lys-Pro-Arg-Pro-Pro-Arg-Arg-Arg-Gln-Arg-Arg-Lys-Lys-Arg-Gly-NH2.
    • HY-15737
      DB07268 Inhibitor 99.49%
      DB07268 是一种有效的选择性 JNK1 抑制剂,IC50 值为 9 nM。
    • HY-11010
      AS601245 Inhibitor 98.32%
      AS601245 是一种 JNK 抑制剂,抑制 hJNK1hJNK2hJNK3IC50 分别为 150, 220 和 70 nM。
    • HY-10366
      BI-78D3 Inhibitor 99.69%
      BI-78D3 是一种底物竞争性的 JNK 抑制剂,抑制 JNK 激酶活性,IC50 为 280 nM。
    • HY-15617
      JNK-IN-7 Inhibitor 98.05%
      JNK-IN-7 是一种有效的 JNK 抑制剂,抑制 JNK1JNK2JNK3IC50 分别为 1.5,2 和 0.7 nM。
    • HY-13022
      CC-401 hydrochloride Inhibitor 99.45%
      CC-401 hydrochloride 是一种有效的 JNK 抑制剂,Ki 为 25 到 50 nM。
    • HY-14761
      Bentamapimod Inhibitor 98.60%
      Bentamapimod (AS 602801) 是一种ATP竞争性的 JNK 抑制剂,作用于 JNK1JNK2JNK3IC50 分别为 80 nM,90 nM 和 230 nM。
    • HY-N0773
      Isovitexin Inhibitor 98.94%
      Isovitexin 是从亚洲水稻种得到的黄酮类物质,具有抗氧化、抗炎的活性;Isovitexin 作用与 JNK1/2 的抑制剂类似,能够抑制 NF-κB 的活化。
    • HY-15881
      TCS JNK 5a Inhibitor 98.91%
      TCS JNK 5a 是一种有效的 JNK3 抑制剂,pIC50 为 6.7。TCS JNK 5a 也抑制 JNK2pIC50为 6.5。
    • HY-12829
      SR-3306 Inhibitor
      SR-3306 是一种有效的可渗透脑的选择性 JNK 抑制剂。
    • HY-N3442
      Juglanin Activator >98.0%
      Juglanin 是一个 JNK 激活剂。
    • HY-N0044
      Ginsenoside Re Inhibitor 98.04%
      Ginsenoside Re (Ginsenoside B2) 是一种 Panax notoginseng 提取物。Ginsenoside Re 可降低 β-淀粉样蛋白 ()。Ginsenoside Re 还通过抑制 JNKNF-κB 发挥抗炎作用。
    • HY-100233
      IQ-1 Inhibitor 98.58%
      IQ-1 是一种 NF-κB/激活蛋白1 (AP-1) 抑制剂,IC50 为 2.3±0.41 μM。IQ-1 对三种 JNK 都具有高的结合亲和力 (Kd 值),对 JNK3JNK1JNK2Kd 值分别为 100 nM,240 nM 和 360 nM。
    Isoform Specific Products

    Your Search Returned No Results.

    Sorry. There is currently no product that acts on isoform together.

    Please try each isoform separately.

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