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    1. MAPK/ERK Pathway
    2. MNK


    Mitogen-activated protein kinase-interacting kinases 1 and 2 (MNK1 and MNK2) phosphorylate the oncogene eIF4E on serine 209. This phosphorylation has been reported to be required for its oncogenic activity. Eukaryotic initiation factor 4E (eIF4E) is a key component of the translational machinery and an important modulator of cell growth and proliferation. The activity of eIF4E is thought to be regulated by interaction with inhibitory binding proteins (4E-BPs) and phosphorylation by mitogen-activated protein (MAP) kinase-interacting kinase (MNK) on Ser209 in response to mitogens and cellular stress.

    MNK Isoform Specific Products:

    • MNK1

    • MNK2

    • MNK

    MNK 相关产品 (5):

    Cat. No. Product Name Effect Purity
    • HY-100022
      Tomivosertib Inhibitor 99.49%
      eFT508 是高选择性,可口服的 MNK1MNK2 抑制剂,其 IC50 值为 1-2 nM。
    • HY-10520
      CGP 57380 Inhibitor 98.48%
      CGP 57380 是一种细胞渗透的吡唑-嘧啶类化合物,为具有选择性的 Mnk1 抑制剂,IC50 值为 2.2 μM,但是对 p38,JNK1,ERK1/2,PKC 或 Src-like 激酶等没有抑制作用。
    • HY-112113
      SLV-2436 Inhibitor 98.13%
      SLV-2436 是一种高效且 ATP 竞争性的 MNK1MNK2 抑制剂,IC50 分别为 10.8 nM 和 5.4 nM。
    • HY-112424
      ETC-206 Inhibitor 99.76%
      ETC-206 是一种选择性 MNK1MNK2 抑制剂,IC50 分别为 64 nM 和 86 nM。
    • HY-16982
      Cercosporamide Inhibitor
      Cercosporamide 是一种高效的 ATP 竞争性 Pkc1 激酶抑制剂,IC50<50 nM,Ki<7 nM。Cercosporamide 是一种独特的 Mnk 抑制剂。
    Isoform Specific Products

    Your Search Returned No Results.

    Sorry. There is currently no product that acts on isoform together.

    Please try each isoform separately.