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    1. MAPK/ERK Pathway
    2. Mixed Lineage Kinase

    Mixed Lineage Kinase

    Mixed lineage kinases (MLKs) are mitogen activated protein kinase kinase kinases (MAPKKKs) with features of both serine-threonine and tyrosine kinases that regulate the c-Jun N-terminal kinase (JNK) mitogen activated protein kinase (MAPK) signaling cascade, and also regulate p38 and extracellular signal-regulated kinase (ERK).

    MLK3 (MAP3K11) is the most widely expressed MLK family member, and is expressed in neurons (as well as other cell types). At the cellular level, MLK3 is activated by stress, including reactive oxygen species, ceramide, and TNFα. At the molecular level, it is activated by Cdc42 and Rac, which interact with MLK3, and can cause it to dimerize via a leucine zipper interface, resulting in autophosphorylation and enzyme activation.

    Mixed Lineage Kinase 相关产品 (3):

    Cat. No. Product Name Effect Purity
    • HY-100573
      (E)-Necrosulfonamide Inhibitor 99.23%
      Necrosulfonamide是一种坏死性凋亡抑制剂,通过选择性靶向 ((MLKL)) 来阻断坏死体形成。
    • HY-12599
      URMC-099 Inhibitor 99.90%
      URMC-099 是一种口服生物有效的混合谱系激酶 3 (MLK3) (IC50=14 nM) 抑制剂,具有优异的血脑屏障穿透性。
    • HY-101524
      TC13172 Inhibitor 99.04%
      TC13172 是 MLKL 的抑制剂,作用于 HT-29 细胞,其 EC50 值为 2 nM。
    Isoform Specific Products

    Your Search Returned No Results.

    Sorry. There is currently no product that acts on isoform together.

    Please try each isoform separately.