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    1. Neuronal Signaling
    2. Monoamine Oxidase

    Monoamine Oxidase

    Monoamine oxidases (MAO) are a family of enzymes that catalyze the oxidation of monoamines. They are found bound to the outer membrane of mitochondria in most cell types in the body. They belong to the protein family of flavin-containing amine oxidoreductases. Monoamine oxidases catalyze the oxidative deamination of monoamines. Oxygen is used to remove an amine group from a molecule, resulting in the corresponding aldehyde and ammonia. Monoamine oxidases contain the covalently bound cofactor FAD and are, thus, classified as flavoproteins. Because of the vital role that MAOs play in the inactivation of neurotransmitters, MAO dysfunction is thought to be responsible for a number of psychiatric and neurological disorders. MAO-A inhibitors act as antidepressant and antianxiety agents, whereas MAO-B inhibitors are used alone or in combination to treat Alzheimer’sand Parkinson’s diseases.

    Monoamine Oxidase 相关产品 (41):

    Cat. No. Product Name Effect Purity
    • HY-B1496
      Tranylcypromine hemisulfate Inhibitor >99.0%
      Tranylcypromine hemisulfate是一种用于治疗抑郁症的不可逆,非选择性 MAO 抑制剂。
    • HY-B1018A
      Phenelzine sulfate Inhibitor 98.70%
      Phenelzine硫酸盐是一种非选择性和不可逆的单胺氧化酶抑制剂 (MAOI), 用作抗抑郁药和抗焦虑药。
    • HY-14197A
      Clorgyline hydrochloride Inhibitor 99.53%
      Clorgyline hydrochloride 是不可逆的,选择性单胺氧化酶A(MAO-A)抑制剂,结构上与Pargyline相关。
    • HY-100546A
      GSK-LSD1 Dihydrochloride Inhibitor >98.0%
      GSK-LSD1 Dihydrochloride是有效,选择性,不可逆的赖氨酸特异性脱甲基酶 (LSD1) 抑制剂,IC50 值为16 nM。
    • HY-A0091
      Pargyline hydrochloride Inhibitor 99.91%
    • HY-B1413
      Eprobemide Inhibitor 99.63%
      Eprobemide 是单胺氧化酶 A (monoamine oxidase A) 的非竞争性可逆抑制剂。
    • HY-13929
      Isocarboxazid Inhibitor >98.0%
      Isocarboxazid 是一种非选择性的、不可逆的单胺氧化酶 monoamine oxidase 抑制剂,其在大鼠大脑中测得的 IC50 值为4.8 μM。
    • HY-W010130
      7-Hydroxy-3,4-dihydro-2(1H)-quinolinone Inhibitor 99.37%
      7-?Hydroxy-?3,?4-?dihydro-?2(1H)?-?quinolinone 是一种弱 MAO-A 抑制剂,IC50 值为 183 μM,对 MAO-B 无作用。
    • HY-N0529
      Rosmarinic acid Inhibitor 99.06%
      迷迭香酸 (Rosmarinic acid) 是一种天然多酚物质,具有抗氧化、抗炎活性。
    • HY-14605
      Rasagiline mesylate Inhibitor
    • HY-16677A
      Mofegiline hydrochloride Inhibitor
      Mofegiline(MDL72974A)盐酸盐是酶活化的不可逆MAO-B抑制剂,对MAO-A和MAO-B的IC50分别为680和3.6 nM。
    • HY-N0159
      Paeonol Inhibitor 99.98%
      Paeonol 是牡丹根的活性提取物,Paeonol 抑制 MAO-AMAO-BIC50 分别为 54.6 μM 和 42.5 μM。
    • HY-70057
      Safinamide Inhibitor 99.77%
      Safinamide (EMD 1195686; FCE 26743)是可逆的MAO-B抑制剂,IC50为98 nM,比对MAO-A的抑制性高5918倍。
    • HY-B0886
      Iproniazid phosphate Inhibitor 99.92%
      Iproniazid是一种非选择性的,不可逆的单胺氧化酶抑制剂 (MAOI)。
    • HY-B0884
      Minaprine Inhibitor
    • HY-B1199
      Nialamide Inhibitor
      Nialamide是一种非选择性的, 不可逆的单胺氧化酶抑制剂 (MAOI), 用作抗抑郁药。
    • HY-14200
      (S)-Rasagiline Inhibitor 99.60%
      (S)-Rasagiline (TVP1022) 是 Rasagiline 的 S 型同分异构体。
    • HY-100027A
      Ro 41-1049 hydrochloride Inhibitor 99.96%
      Ro 41-1049盐酸盐是一种选择性的单胺氧化酶A型(MAO-A)抑制剂。
    • HY-B0884A
      Minaprine dihydrochloride Inhibitor 99.82%
    • HY-14201
      Lazabemide Inhibitor 99.71%
      Lazabemide(Ro 19-6327) 是MAO-B选择性可逆性抑制剂,IC50 值为 30 nM,对MAO-A无活性(IC50>100uM)。
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