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    1. Cytoskeleton
    2. Myosin


    Myosin light chain kinase (MLCK) is a ubiquitous Ca2+/calmodulin (CaM)-activated kinase found in smooth, cardiac, and skeletal muscle as well as in mammalian nonmuscle cells.

    Myosin light chain kinase (MLCK) is a regulatory protein forsmooth muscle contraction, which acts by phosphorylating 20-kDamyosin light chain (MLC20) to activate the myosin ATPase activity.Myosin light chain kinase (MLCK) of smooth muscle hasbeen puried as an enzyme that phosphorylates 20-kDa lightchain of smoothmuscle myosin (MLC20).

    Analysis of the cross talk between Ras-ERK and PI3K-AKT signaling pathways reveals integrin β1, myosin light chain kinase (MLCK) and myosin IIA are required for the activation of PI3K-AKT following inhibition of the Ras-ERK pathway. Integrin β1, MLCK, and myosin IIA are factors in the development of resistance to MEK inhibitors.

    Myosin light chain kinase (MLCK) phosphorylates the regulatory light chain (RLC) of myosin producing increases in force development during skeletal muscle contraction.

    Myosin 相关产品 (9):

    Cat. No. Product Name Effect Purity
    • HY-13441
      (-)-Blebbistatin Inhibitor 99.42%
      (-)-Blebbistatin是布雷他汀的S对映体。 Blebbistatin是有效且选择性的 myosin II 抑制剂,IC50 范围为0.5至5 μM。
    • HY-14233
      Omecamtiv mecarbil Activator 99.28%
      Omecamtiv mecarbil是心肌肌球蛋白激活剂。
    • HY-15417
      ML-7 hydrochloride Inhibitor 98.18%
      ML-7 hydrochloride 是一种萘磺酰胺衍生物,有效抑制 MLCK (IC50=300 nM) 和 TRPC6 通道 (IC50>10 μM)。
    • HY-100984
      HA-100 Inhibitor 99.76%
      HA-100 是 cGMP 依赖性蛋白激酶 (PKG),cAMP 依赖性蛋白激酶 (PKA),蛋白激酶 C (PKC) 和 MLC 激酶 (MLC-kinase) 的抑制剂,其 IC50 值分别为 4, 8, 12 和 240 μM。
    • HY-16690
      BTS Inhibitor 99.78%
      BTS是钙离子刺激的肌球蛋白S1ATP酶抑制剂(IC50为 5 μM),能可逆地阻断滑行运动。
    • HY-109037
      Mavacamten Modulator >99.0%
      Mavacamten 是心肌肌球蛋白的调节剂,其在牛心脏和人心脏中的 IC50 值分别为 490,711 nM。
    • HY-P1029
      MLCK inhibitor peptide 18 Inhibitor 98.71%
      MLCK inhibitor peptide 18 是一种有效的 MLCK 抑制剂,IC50 值为 50 nM,同时较弱抑制 CaM kinase II 的活性。
    • HY-100685
      MS-444 Inhibitor
      MS-444 是平滑肌肌球蛋白轻链激酶 (MLCK) 的抑制剂,IC50 值为 10 μM。
    • HY-100948
      ATM-3507 Inhibitor
      ATM-3507 是原肌球蛋白 (tropomyosin) 的一个有效抑制剂,其在人类黑色素瘤细胞系中的 IC50 值约为 3.83-6.84 μM。
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