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    1. Immunology/Inflammation
    2. NOD-like Receptor (NLR)

    NOD-like Receptor (NLR)

    Nucleotide oligomerization domain (NOD)-like receptors (NLRs) are a specialized group of intracellular proteins that play a critical role in the regulation of the host innate immune response. NLRs act as scaffolding proteins that assemble signaling platforms that trigger nuclear factor-κB and mitogen-activated protein kinase signaling pathways and control the activation of inflammatory caspases. Importantly, mutations in several members of the NLR family have been linked to a variety of inflammatory diseases consistent with these molecules playing an important role in host-pathogen interactions and the inflammatory response. NLRs including Nod1 and Nod2 are thought to be kept in an inactive state by intra-molecular interactions.

    The central role of the Nod-like receptor (NLR) protein family became increasingly appreciated in innate immune responses. NLRs are classified as part of the signal transduction ATPases with numerous domains (STAND) clade within the AAA+ ATPase family.

    NOD-like Receptor (NLR) 相关产品 (9):

    Cat. No. Product Name Effect Purity
    • HY-12815A
      MCC950 sodium Inhibitor 98.90%
      MCC950 sodium是一种有效,选择性的 NLRP3 抑制剂,在BMDMs 和 HMDMs中的 IC50 分别为 7.5 nM 和 8.1 nM。
    • HY-12815
      MCC950 Inhibitor >98.0%
      MCC950 是一种有效,选择性的 NLRP3 抑制剂,在BMDMs 和 HMDMs中的IC50 分别为 7.5 nM 和 8.1 nM。
    • HY-103666
      CY-09 Inhibitor >98.0%
      CY-09 是 NLRP3 的抑制剂。
    • HY-100691
      NOD-IN-1 Inhibitor 98.99%
      NOD-IN-1 是一种有效的核苷酸结合寡聚化结构域 (NOD) 样受体 NOD1 和 NOD2 的抑制剂,IC50 值分别为 5.74 μM 和 6.45 μM。
    • HY-18639
      Nodinitib-1 Inhibitor >98.0%
      Nodinitib-1 (ML130;CID-1088438)是NOD1抑制剂,IC50值为0.56 μM。
    • HY-101868
      INF39 Inhibitor 99.61%
      INF39 是不可逆的,没有细胞毒性的NLRP3 抑制剂。
    • HY-N0139
      Troxerutin Inhibitor 98.05%
      Troxerutin 也被称为维生素 P4,是天然生物类黄酮芦丁的三羟乙基化衍生物,其可抑制活性氧 (ROS) 的产生并抑制 ER 应激介导的 NOD 活化。
    • HY-16059
      Arglabin Inhibitor 99.17%
    • HY-N0727
      seco-Isolariciresinol Diglucoside Inhibitor 99.74%
      seco-Isolariciresinol Diglucoside 是一种合成的木脂素。来源于天然植物亚麻籽。作用于巨噬细胞,降低 NLRP3 表达和 NF-κB 活化。seco-Isolariciresinol Diglucoside 还激活 Nrf2
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