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    1. Membrane Transporter/Ion Channel
    2. Na+/K+ ATPase

    Na+/K+ ATPase

    Na+/K+ ATPase (Sodium potassium pump) is a transmembrane protein complex found in all higher eukaryotes acting as a key energy-consuming pump maintaining ionic and osmotic balance in cells. Na+/K+ ATPase is an emerging cancer target that merits further investigation.

    The constant activity of the Na+/K+-ATPase (NKA, or Na+ pump) is essential for re-establishing and maintaining this gradient. In cardiac and vascular smooth muscle the principal isoforms of the NKA are α1 and α2 and their physiological role is controlled both by their unique and independent signalling pathways, and their discrete subcellular distribution.

    Na+/K+ ATPase 相关产品 (14):

    Cat. No. Product Name Effect Purity
    • HY-B1049
      Digoxin Inhibitor 98.92%
      Digoxin是 Na+/K+-ATPase 的有效抑制剂,临床上用于治疗心律失常和心力衰竭。
    • HY-B0542
      Ouabain Octahydrate Inhibitor 99.91%
      Ouabain Octahydrate 是 Na+/K+-ATPase 抑制剂,常用于治疗充血性心力衰竭。
    • HY-15718A
      Istaroxime hydrochloride Inhibitor 99.32%
      Istaroxime hydrochloride是 Na+/K+-ATPase 抑制剂 (IC50=0.11 μM) 和肌浆/内质网钙ATP酶2 (SERCA 2) 激活剂。
    • HY-N0143
      Phlorizin Inhibitor
      Phlorizin 是一种非选择性的 SGLT 抑制剂,对于 hSGLT1hSGLT2Ki 值分别为 300 和 39 nM。Phlorizin 也是一个 Na+/K+-ATPase 抑制剂。
    • HY-B1357
      Digitoxin Inhibitor 98.23%
      Digitoxin是有效的 Na+/K+-ATPase抑制剂, EC50 值为0.78 μM。
    • HY-N2070
      Acevaltrate Inhibitor 99.56%
      Acevaltrate 从 Valeriana glechomifolia 中分离,抑制大鼠肾和脑半球中 Na+/K+-ATP 酶活性,IC50 分别为 22.8±1.1 μM 和 42.3±1.0 μM。
    • HY-12283
      Rostafuroxin Antagonist
      Rostafuroxin(PST 2238)是一种抗高血压化合物Na+K ATPase拮抗剂;IC50为1.5 nM。
    • HY-N0039
      Ginsenoside Rb1 Inhibitor >98.0%
      Ginsenoside Rb1 是中药 Panax ginseng 的成分。Ginsenoside 抑制 Na+, K+-ATPase 活性,IC50 为 6.3±1.0 μM。Ginsenoside Rb1 也抑制 IRAK-1 激活及 NF-κB p65 的磷酸化。
    • HY-13719
      Oleandrin Inhibitor 99.84%
      Oleandrin 抑制 Na+, K+-ATPase 活性,IC50 为 620 nM。
    • HY-19556
      (+)-SJ733 Inhibitor 99.45%
      (+)-SJ733 是临床上治疗疟疾的候选物,也是一个 Na+-ATPase PfATP4 抑制剂。
    • HY-B1429
      Chlorpropamide Inhibitor 99.24%
      Chlorpropamide是一种口服降糖剂, 用于治疗非胰岛素依赖型糖尿病 (NIDDM)。
    • HY-15718
      Istaroxime Inhibitor
      Istaroxime (PST2744) 是一种有效的 Na+,K+-ATPase 抑制剂,IC50 值为 0.11 μM。
    • HY-B0137A
      Prilocaine hydrochloride Inhibitor
      Prilocaine是局麻化合物。
    • HY-B0137
      Prilocaine Inhibitor
      Prilocaine是局麻化合物。
    Isoform Specific Products

    Your Search Returned No Results.

    Sorry. There is currently no product that acts on isoform together.

    Please try each isoform separately.

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