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    1. GPCR/G Protein
      Neuronal Signaling
    2. Neurokinin Receptor

    Neurokinin Receptor

    There are three main classes of neurokinin receptors: NK1R (the substance P preferring receptor), NK2R, and NK3R. These tachykinin receptors belong to the class I (rhodopsin-like) G-protein coupled receptor (GPCR) family. The various tachykinins have different binding affinities to the neurokinin receptors: NK1R, NK2R, and NK3R. These neurokinin receptors are in the superfamily of transmembrane G-protein coupled receptors (GPCR) and contain seven transmembrane loops. Neurokinin-1 receptor interacts with the Gαq-protein and induces activation of phospholipase C followed by production of inositol triphosphate (IP3) leading to elevation of intracellular calcium as a second messenger. Further, cyclic AMP (cAMP) is stimulated by NK1R coupled to the Gαs-protein. The neurokinin receptors are expressed on many cell types and tissues.

    Neurokinin Receptor 相关产品 (44):

    Cat. No. Product Name Effect Purity
    • HY-P0201
      Substance P Modulator 98.07%
      Substance P 是一种神经肽,作为神经递质和神经调节剂。Substance P 的内源性受体是神经激肽1受体 (neurokinin 1 receptorNK1R)。
    • HY-10052
      Aprepitant Inhibitor 99.93%
      Aprepitant (MK-0869) 是选择性和高亲和力的神经激肽1受体拮抗剂,Kd 值为86 pM。
    • HY-15722
      SB-222200 Antagonist 99.91%
      SB 222200是可逆的竞争性人NK受体抑制剂,对hNK-3受体的Ki为4.4 nM,能透过血脑屏障。
    • HY-14751
      Rolapitant Antagonist 98.01%
      Rolapitant (SCH619734)是高效选择性具有口服活性的 neurokinin NK1 受体抑制剂,Ki值为0.66 nM。
    • HY-19632
      Fezolinetant Antagonist 98.29%
      Fezolinetant 是一种神经激肽-3 受体 (neurokinin 3 receptor) 拮抗剂,可用于更年期潮热的研究。
    • HY-P1276A
      Men 10376 TFA Antagonist
      Men 10376 TFA 是一种有效的选择性的 tachykinin NK-2 受体拮抗剂,对大鼠小肠 NK-2 受体的 Ki 值为 4.4 μM。
    • HY-P0236A
      Neurokinin A(4-10) TFA Agonist
      Neurokinin A (4-10) TFA 是速激肽 NK2 受体激动剂。
    • HY-P1012
      [Sar9,Met(O2)11]-Substance P Agonist 98.45%
      [Sar9,Met(O2)11]-Substance P 是一种选择性的速激肽 NK1 受体激动剂。
    • HY-P0187
      Senktide Agonist 99.56%
      Senktide 是一种速激肽 NK3 受体激动剂。
    • HY-16346
      Netupitant Antagonist 99.78%
      Netupitant (CID-6451149) 是一高效、选择性、口服活性的Neurokinin-1受体(NK1)拮抗剂,Ki值为0.95nM。
    • HY-14407A
      Fosaprepitant dimeglumine Antagonist >99.0%
      Fosaprepitant dimeglumine(MK-0517)是神经激肽-1受体拮抗剂,可作用于化疗引起的恶心呕吐。
    • HY-14432
      Pavinetant Antagonist 99.74%
      Pavinetant (MLE-4901) 是一种神经激肽-3 受体 (NK3R) 拮抗剂。
    • HY-10053
      Maropitant Antagonist 99.00%
      Maropitant是神经激肽(NK1)受体拮抗剂。
    • HY-18006
      NKP608 Antagonist 99.34%
      NKP608为非肽类4-氨基哌啶衍生物,是神经激肽-1(NK-1)受体拮抗剂,IC50为2.6 nM。
    • HY-P1031
      [bAla8]-Neurokinin A(4-10) Agonist 98.17%
      [bAla8]-Neurokinin A(4-10) 是一种神经激肽-2 受体 (neurokinin 2 receptor) 激动剂。
    • HY-P1485
      Substance P 1-7
      Substance P (7-11) 是神经肽P物质 (SP) 的片段。Substance P (7-11) 可对孤束核产生抑制和缓和作用。
    • HY-16346S
      Netupitant D6 Antagonist
      Netupitant D6是Netupitant(CID-6451149)氘代化合物标准品。
    • HY-12114
      Serlopitant Antagonist
      Serlopitant是一种选择性的 神经激肽-1 (NK-1) 受体拮抗剂。
    • HY-P1485A
      Substance P (1-7)(TFA) 99.20%
      Substance P (1-7)(TFA) 是神经肽 P 物质 (SP) 的片段。Substance P (1-7)(TFA) 可对孤束核产生抑制和缓和作用。
    • HY-101704
      Y1 receptor antagonist 1 Antagonist
      Y1 receptor antagonist 1 是 H-409/22 的一个异构体,是神经肽 (neuropeptide Y1) 受体拮抗剂。
    Isoform Specific Products

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