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    1. GPCR/G Protein
      Neuronal Signaling
    2. Opioid Receptor

    Opioid Receptor

    Opioid receptors are a group of G protein-coupled receptors with opioids as ligands. The endogenous opioids are dynorphins, enkephalins, endorphins, endomorphins and nociceptin. Opioid receptors are distributed widely in the brain, and are found in the spinal cord and digestive tract. Opioid receptors are molecules, or sites, within the body that are activated by opioid substances. Opioid receptors inhibit the transmission of impulse in excitatory pathways within the human body system. These pathways include the serotonin, catecholamine, and substance P pathways, which are all implicated in pain perception and feelings of well-being. Opioid receptors are further subclassified into mu, delta, and kappa receptors. All the classes, while exhibiting differing modes of action, share some basic similarities. They all are driven by the potassium pump mechanism, which is found on the plasma membrane of the majority of cells.

    Opioid Receptor 相关产品 (60):

    Cat. No. Product Name Effect Purity
    • HY-101386
      PZM21 Agonist 99.45%
      PZM21是高效选择性的μ opioid receptor受体激动剂,EC50值为1.8 nM。
    • HY-B0418A
      Loperamide hydrochloride Agonist 99.69%
      Loperamide (hydrochloride) (R-18553 (hydrochloride)) 是用于治疗腹泻的阿片受体 (opioid receptor) 激动剂。
    • HY-13044
      ADL-5859 Agonist 99.65%
      ADL5859是δ-阿片受体选择性激动剂,Ki为0.8 nM,对hERG有弱抑制性。
    • HY-16655A
      Oliceridine hydrochloride Agonist 98.70%
      Oliceridine hydrochloride (TRV130 hydrochloride) 是新颖的 MOR 激动剂,能够优先激活 G-protein 信号通路,而对 β-arrestin 的作用稍弱。
    • HY-10487
      JDTic dihydrochloride Antagonist 99.79%
      JDTic dihydrochloride 是一种有效的 kappa-opioid receptors (KOR) 的拮抗剂,常用于神经系统疾病的研究。
    • HY-A0118A
      Naloxegol oxalate Antagonist 99.90%
      Naloxegol oxalate (NKTR-118 oxalate; AZ-13337019 oxalate) 是阿片受体拮抗剂。
    • HY-P1594A
      Dynorphin A (1-10) TFA Agonist
      Dynorphin A (1-10) (TFA) 是一种内源性的阿片样神经肽,与 κ 阿片受体 (κ-opioid receptor) 结合。Dynorphin A (1-10) (TFA) 也阻断 NMDA 激活的电流,IC50 为 42.0 μM。
    • HY-A0118
      Naloxegol Antagonist
      Naloxegol (NKTR-118; AZ-13337019) 是阿片受体拮抗剂。
    • HY-G0021
      N-Desmethylclozapine Agonist 98.66%
      N-Desmethylclozapine 是登革病毒抑制剂,同时为 δ-opioid 受体的激动剂。
    • HY-N0164
      Matrine Agonist >98.0%
      Matrine (Matridin-15-one) 是来源于植物的生物碱,有抗肿瘤活性,是kappa阿片受体激动剂。
    • HY-101177
      Naltrindole hydrochloride Antagonist 99.68%
      Naltrindole hydrochloride是高效,选择性的非多肽类 δ opioid 受体拮抗剂,Ki值为0.02 nM。
    • HY-101718
      Aticaprant Antagonist 99.24%
      Aticaprant (CERC-501) 是一种有效地可渗透中枢神经的kappa opioid受体拮抗剂,Ki值为0.807 nM。
    • HY-P0210
      DAMGO Agonist 98.10%
      DAMGO 是 一种选择性的 μ-阿片受体 (μ-OPR) 激动剂。
    • HY-15536
      Cebranopadol Agonist 98.76%
      Cebranopadol 是NOPopioid receptor 激动剂,作用于人NOP,MOP,KOP 和δ-阿片肽(DOP)受体,Ki/EC50 分别为 0.9 nM/13 nM,0.7 nM/1.2 nM,2.6 nM/17 nM,18 nM/110 nM。
    • HY-13274
      JTC-801 Antagonist 99.20%
      JTC-801 是一种具有选择性的 opioid receptor-like1 (ORL1) receptor 抑制剂,其 Ki 值为 8.2 nM。
    • HY-P0073
      Tyr-Gly-Gly-Phe-Met-OH Activator 99.81%
      Tyr-Gly-Gly-Phe-Met-OH 通过结合阿片样物质受体 (opioid receptor),可调控人类免疫功能,抑制肿瘤生长。
    • HY-15122A
      Sinomenine hydrochloride Activator >98.0%
      Sinomenine hydrochloride 是 NF-κB 活化的阻断剂,也是 μ 阿片受体 (μ-opioid receptor) 的激活剂。
    • HY-P0288
      [Leu5]-Enkephalin Agonist 99.72%
      [Leu5]-Enkephalin 是一种具有吗啡药性的五肽。作为阿片受体 (opioid receptors) 激动剂。
    • HY-111454
      SR17018 Agonist >98.0%
      SR17018 是一种 mu 型阿片受体 (mu-opioid-receptor) 激动剂,能够与 GTPγS 结合,EC50 值为 97 nM。
    • HY-P0183
      Nociceptin Agonist 99.79%
      Nociceptin 是一种十七肽,为 nociceptin 受体的内源性配体,具有镇痛作用。
    Isoform Specific Products

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