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    1. Signaling Pathways
    2. Membrane Transporter/Ion Channel
    3. P-glycoprotein


    P-glycoprotein (P-gp) also known as multidrug resistance protein 1 (MDR1) is an important protein of the cell membrane that pumps many foreign substances out of cells. More formally, it is an ATP-dependent efflux pump with broad substrate specificity. P-gp is extensively distributed and expressed in the intestinal epithelium where it pumps xenobiotics (such as toxins or drugs) back into the intestinal lumen, in liver cells where it pumps them into bile ducts, in the cells of the proximal tubular of the kidney where it pumps them into urine-conducting ducts, and in the capillary endothelial cells comprising the blood–brain barrier and blood-testis barrier, where it pumps them back into the capillaries. Some cancer cells also express large amounts of P-gp, which renders these cancers multi-drug resistant. P-gp is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood–brain barrier.

    P-glycoprotein 相关产品 (26):

    Cat. No. Product Name Effect Purity
    • HY-50879
      Elacridar Inhibitor 98.47%
      Elacridar 是一种有效的 P-糖蛋白 (P-glycoprotein) 和 BCRP 的抑制剂。
    • HY-17384
      Valspodar Inhibitor 99.27%
    • HY-50671
      Zosuquidar trihydrochloride Inhibitor 98.75%
      Zosuquidar trihydrochloride是P-糖蛋白的抑制剂, Ki值为59 nM。
    • HY-10550
      Tariquidar Inhibitor 98.57%
      Tariquidar 是一种有效的特异性P-glycoprotein (P-gp)抑制剂,Kd 为 5.1±0.9 nM。
    • HY-11018
      Risperidone Inhibitor 99.16%
      Risperidone是 5-HT2 受体的阻断剂,P-糖蛋白 (P-Glycoprotein) 的抑制剂 和 dopamine D2 受体的拮抗剂,其对 5-HT2A 和 dopamine D2 受体的 Ki 值分别为 4.8,5.9 nM。
    • HY-128685
      FD 12-9 Inhibitor
      FD 12-9 是一种类黄酮二聚体,为 P-gpBCRP 的双重抑制剂,EC50 值分别为 285 nM 和 0.9 nM。具有抗胶质细胞瘤活性。
    • HY-112912
      P-gp modulator 1
      P-gp modulator 1 是一种高亲和力、口服有效的 p- 糖蛋白 (Pgp) 调节剂,可以逆转 Pgp 介导的多药抗性。
    • HY-101791
      P-gp inhibitor 1 Inhibitor
      P-gp inhibitor 1是一种新型的可逆转P-糖蛋白介导的多药耐药性抑制剂。
    • HY-10550A
      Tariquidar methanesulfonate, hydrate Inhibitor 98.02%
      Tariquidar methanesulfonate, hydrate是有效和特异性的 P-glycoprotein (P-gp) 抑制剂,Kd值为5.1 nM。
    • HY-15255
      Zosuquidar Inhibitor 98.33%
      Zosuquidar (LY335979)是P-糖蛋白(P-gp)介导的多药抗性负调节剂,Ki为60 nM。
    • HY-N0450
      Sinapine thiocyanate Inhibitor 98.32%
    • HY-13646
      Encequidar Inhibitor 98.12%
      Encequidar (HM30181) 是一种有效的选择性的P-glycoprotein抑制剂。
    • HY-N0144
      Piperine Inhibitor 98.76%
      Piperine是从胡椒中分离的天然生物碱,可以抑制P-glycoprotein and CYP3A4的活性,在HeLa细胞中的IC50值为61.94±0.054 μg/mL。
    • HY-N5077
      Sinapine Inhibitor 99.72%
    • HY-N0797
      (20S)-Protopanaxadiol Inhibitor >98.0%
      (20S)-Protopanaxadiol (20-Epiprotopanaxadiol)是protopanaxadiol型人参皂苷的糖苷配基代谢衍生物,为凋亡诱导剂。
    • HY-17013A
      Dofequidar fumarate Inhibitor 99.99%
      Dofequidar 延胡索酸盐(MS-209 延胡索酸盐)是口服活性的喹啉化合物,能抑制 ABCB1/P-gp,ABCC1/MDR-相关蛋白1。
    • HY-19626
      NSC23925 Inhibitor 99.23%
      NSC23925 是一种新型的,有选择性且有效的 P-糖蛋白 (Pgp) 抑制剂。
    • HY-106004
      Zamicastat Inhibitor 99.95%
      Zamicastat (BIA 5-1058) 是 多巴胺 β-羟化酶 (DBH)的抑制剂,可通过血脑屏障引起中枢和周边效应。Zamicastat 也是一种浓度依赖性的双重 P-gpBCRP 抑制剂,IC50 值分别为 73.8 μM 和 17.0 μM。具有降血压作用。
    • HY-17013
      Dofequidar Inhibitor
    • HY-N0854
      Alisol F Inhibitor
      泽泻醇F (Alisol F) 是一种天然化合物。
    Isoform Specific Products

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    Please try each isoform separately.