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    1. Immunology/Inflammation
    2. PD-1/PD-L1

    PD-1/PD-L1

    Programmed death-1 (PD-1) is a receptor on T cells that has been shown to suppress activating signals from the T cell receptor when bound by either of its ligands, Programmed death-ligand 1 (PD-L1) or PD-L2. When PD-1 expressing T cells contact cells expressing its ligands, functional activities in response to antigenic stimuli, including proliferation, cytokine secretion, and cytotoxicity are reduced. PD-1/PD-Ligand interactions down regulate immune responses during resolution of an infection or tumor, or during the development of self tolerance.

    Interference with the PD-1/PD-L1 interaction has also shown enhanced T cell activity in chronic infection systems. Chronic lymphocytic chorio meningitis virus infection of mice also exhibits improved virus clearance and restored immunity with blockade of PD-L1.

    In addition to enhancing immunologic responses to chronic antigens, blockade of the PD-1/PD-L1 pathway has also been shown to enhance responses to vaccination, including therapeutic vaccination in the context of chronic infection.

    PD-1/PD-L1 相关产品 (10):

    Cat. No. Product Name Effect Purity
    • HY-19745
      BMS-202 Inhibitor 99.37%
      BMS-202 是 PD-1/PD-L1 相互作用抑制剂,主要用于抗癌研究。
    • HY-19991
      BMS-1 Inhibitor 99.61%
      BMS-1 是 PD-1/PD-L1 蛋白质/蛋白质相互作用的抑制剂,IC50 为 6 到 100 nM。
    • HY-P9903
      Nivolumab Inhibitor 98.56%
      Nivolumab 是一种 PD-1 抗体类抑制剂,用于晚期(转移性)非小细胞肺癌的研究。
    • HY-P9904
      Atezolizumab Inhibitor 98.98%
      Atezolizumab 是一种人源化单克隆抗体 IgG1,抵抗程序性死亡因子配体1 (PD-L1),用于癌症研究。
    • HY-101093
      PD-1-IN-1 Inhibitor 98.48%
      PD-1-IN-1是PD-1的抑制剂, 来自专利WO 2015033299 A1,化合物实例4。
    • HY-102011
      BMS-1166 Inhibitor
      BMS-1166 是 PD-1/PD-L1 相互作用的有效抑制剂,其 IC50 值为 1.4 nM。
    • HY-P9902
      Pembrolizumab Inhibitor 98.56%
      Pembrolizumab 是一种人源化抗体,为 PD-1 的抑制剂,用于癌症免疫的研究。
    • HY-108730
      Avelumab Inhibitor
      Avelumab 是一个人 IgG1 抗 PD-L1 单克隆抗体,具有潜在的抗体依赖性细胞介导的细胞毒性作用。
    • HY-B0333
      Sulfamethizole Inhibitor 99.71%
      Sulfamethizole是磺胺噻唑类抗生素,能抑制细菌的PABA。
    • HY-101098
      PD1-IN-2 Inhibitor
      PD1-IN-2 是 PD1 信号通路抑制剂,是一种免疫调节剂。
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