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    1. PI3K/Akt/mTOR
    2. PDK-1


    PDK-1 (phosphoinositide dependent protein kinase-1) is a protein which in humans is encoded by the PDK1 gene. It is implicated in the development and progression of melanomas. PDK-1 is a master kinase, which is crucial for the activation of AKT/PKB and many other AGC kinases including PKC, S6K, SGK. An important role for PDK-1 is in the signalling pathways activated by several growth factors and hormones including insulin signaling. More recent data indicate that alteration of PDK-1 is a critical component of oncogenic PI3K signalling in breast cancer, suggesting that inhibition of PDK-1 can inhibit breast cancer progression. PDK-1 has an essential role in regulating cell migration especially in the context of PDK-1 deficiency. PDK-1 is a valid therapeutic target and suggests that PDK-1 inhibitors may be useful to prevent cancer progression and abnormal tissue dissemination.

    PDK-1 相关产品 (7):

    Cat. No. Product Name Effect Purity
    • HY-10514
      BX795 Inhibitor 99.33%
      BX795是有效,选择性的 PDK1 抑制剂,IC50为6 nM, 比PKA,PKC,c-Kit,GSK3β的选择性高50多倍。
    • HY-14981
      GSK2334470 Inhibitor 99.78%
      GSK2334470是高效特异性的 PDK1 抑制剂,IC50值为10 nM。
    • HY-15967
      PS48 Activator 99.97%
      PS48 是 一种 PDK1 激活剂,AC50 为 8 μM。
    • HY-14440
      MP7 Inhibitor 99.36%
      MP7 是一种磷酸肌醇依赖性激酶-1 (PDK1) 抑制剂。
    • HY-13842
      BX517 Inhibitor >98.0%
      BX517 是一种有效的,选择性的 PDK1 抑制剂,IC50 值为 6 nM。
    • HY-11005
      BX-912 Inhibitor 98.94%
      BX-912 是一种有效的 PDK1 抑制剂,IC50 为 12 nM。
    • HY-10547
      OSU-03012 Inhibitor 98.74%
      OSU-03012 是一种 PDK-1 抑制剂,IC50 为 5 μM。
    Isoform Specific Products

    Your Search Returned No Results.

    Sorry. There is currently no product that acts on isoform together.

    Please try each isoform separately.