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    1. Immunology/Inflammation
    2. PGE synthase

    PGE synthase

    PGE synthase (Prostaglandin E synthase), which converts cyclooxygenase (COX)-derived prostaglandin (PG) H2 to PGE2, occurs in multiple forms with distinct enzymatic properties, modes of expression, cellular and subcellular localizations and intracellular functions. Cytosolic PGES (cPGES) is a cytosolic protein that is constitutively expressed in a wide variety of cells and tissues and is associated with heat shock protein 90 (Hsp90). Membrane-associated PGES (mPGES), the expression of which is stimulus-inducible and is downregulated by anti-inflammatory glucocorticoids, is a perinuclear protein belonging to the microsomal glutathione S-transferase (GST) family. These two PGESs display distinct functional coupling with upstream COXs in cells; cPGES is predominantly coupled with the constitutive COX-1, whereas mPGES is preferentially linked with the inducible COX-2. Several cytosolic GSTs also have the capacity to convert PGH2 to PGE2 in vitro. Accumulating evidence has suggested that mPGES participates in various pathophysiological states in which COX-2 is involved, implying that mPGES represents a potential novel target for drug development.

    PGE synthase 相关产品 (12):

    Cat. No. Product Name Effect Purity
    • HY-N0297
      Sinensetin Inhibitor 99.22%
      Sinensetin是一个能够在水果中发现的甲基化黄酮,有很强的抗血管和抗炎症的能力.
    • HY-B0890
      Zomepirac sodium salt Inhibitor 99.40%
      Zomepirac钠盐是一种前列腺素合成酶抑制剂。
    • HY-B0683
      Limaprost Agonist 99.76%
      Limaprost(OP1206)是PGE1类似物,是血小板粘附抑制剂。
    • HY-10582
      Flurbiprofen Inhibitor 99.85%
      Flurbiprofen是非甾体抗炎化合物,有退热止痛的效果。
    • HY-13283
      MF63 Inhibitor 98.94%
      MF63是mPGES-1抑制剂,对猪mPGES-1和人mPGES-1的IC50分别为0.9 nM和1.3 nM。
    • HY-B0550
      Bismuth Subsalicylate Inhibitor
      Bismuth Subsalicylate能抑制前列腺素G/H合酶1/2。
    • HY-12791
      hPGDS-IN-1 Inhibitor
      hPGDS-IN-1是一种hPGDS抑制剂, 荧光偏振检测或EIA法测得IC50值为12 nM。
    • HY-B0270
      Suprofen Inhibitor 99.44%
      Suprofen (TN-762) 是非甾体抗炎化合物,能抑制前列腺素合成。
    • HY-30235A
      Benzydamine hydrochloride Inhibitor 98.79%
      Benzydamine盐酸盐是前列腺素合成酶抑制剂,抗炎症,还报道有抗细菌活性。
    • HY-B0336
      Pranoprofen Inhibitor 98.48%
      Pranoprofen是非甾体抗炎化合物,可作用于眼科疾病。
    • HY-10439
      HPGDS inhibitor 1 Inhibitor 99.49%
      HPGDS inhibitor 1是造血前列腺素D合成酶(HPGDS)抑制剂,IC50为0.7 nM。
    • HY-101587
      PGS-IN-1 Inhibitor
      PGS-IN-1是有效的前列腺素合成酶 (prostaglandin synthetase) 抑制剂,IC50 值为0.28 μM;也可抑制5-脂肪氧合酶 (5-lipoxygenase) 的活性,IC50 值为 1.05 μM。
    Isoform Specific Products

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