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    1. PI3K/Akt/mTOR
    2. PI4K


    The phosphatidylinositol 4-kinases (PI4Ks) synthesize phosphatidylinositol 4-phosphate (PI4P), a key member of the phosphoinositide family. PI4P defines the membranes of Golgi and trans-Golgi network (TGN) and regulates trafficking to and from the Golgi.

    In mammals there are four different PI4K enzymes, two type II enzymes (PI4KIIα and PI4KIIβ) and two type III enzymes (PI4KIIIα and PI4KIIIβ). PI4KIIIβ plays key roles in mediating lipid transport, cytokinesis, maintaining lysosomal identity, and in tandem with Rab GTPases plays key roles in regulating membrane trafficking. PI4KIIIβ is critical for mediating viral replication of a number of RNA viruses through the generation of PI4P enriched viral replication platforms. Small molecule inhibitors of PI4KIIIβ are potent anti-viral agents. Development of PI4KIIIβ as an effective drug target for anti-viral therapeutics requires the generation of highly potent and specific inhibitors.

    PI4K Isoform Specific Products:

    • PI4KIIIβ

    • PI4KIIIα

    • PI4K

    PI4K 相关产品 (10):

    Cat. No. Product Name Effect Purity
    • HY-12046
      PIK-93 Inhibitor 99.13%
      PIK-93 是一种合成的,有效的 PI4KIIIβ 抑制剂,IC50 值为 19 nM,同时可抑制 PI3KγPI3Kα 的活性,IC50 值分别为 16 nM 和 39 nM。
    • HY-100198
      PI4KIIIbeta-IN-10 Inhibitor 98.90%
      PI4KIIIbeta-IN-10 是一种有效的 PI4KIIIβ 抑制剂,IC50 为 3.6 nM。
    • HY-19798
      PI4KIIIbeta-IN-9 Inhibitor 98.16%
      PI4KIIIbeta-IN-9 是一种有效的 PI4KIIIβ 抑制剂,IC50 为 7 nM。PI4KIIIbeta-IN-9 也抑制 PI3KδPI3KγIC50 分别为 152 nM 和 1046 nM。
    • HY-15679
      PI4KIII beta inhibitor 3 Inhibitor
      PI4KIII beta inhibitor 3 是一种新型高效的 ΡΙ4ΚΙΙΙβ 抑制剂,IC50 为 5.7 nM。
    • HY-12912
      KDU691 Inhibitor 99.46%
      KDU691 是一个 PI4K 抑制剂。
    • HY-112435
      UCT943 Inhibitor
      UCT943 是新一代恶性疟原虫 Plasmodium falciparum PI4K 抑制剂。UCT943 抑制 P. vivax PI4K (PvPI4K) 酶,IC50 为 23 nM。
    • HY-112613
      UCB9608 Inhibitor 99.12%
      UCB9608 是一种有效、选择性、可口服的 PI4KIIIβ 抑制剂,IC50 值为 11 nM,对其选择性高于 PI3KC2 α,β 和 γ。UCB9608 增加了代谢稳定性,表现出良好的药代动力学特征,可作为免疫抑制剂。
    • HY-18748
      BQR-695 Inhibitor 99.78%
      BQR-695 是一种 PI4KIIIβ 抑制剂,对于人类和疟原虫 PI4KIIIβ 的 IC50 值分别为 80 和 3.5 nM。
    • HY-108313
      T-00127_HEV1 Inhibitor 99.97%
      T-00127_HEV1 是一个 phosphatidylinositol 4-kinase III beta (PI4KB) 抑制剂,其 IC50 值为 60 nM。
    • HY-U00426
      BF738735 Inhibitor
      BF738735 是一种磷脂酰肌醇 4-激酶 IIIβ (PI4KIIIβ) 抑制剂,IC50 为 5.7 nM。
    Isoform Specific Products

    Your Search Returned No Results.

    Sorry. There is currently no product that acts on isoform together.

    Please try each isoform separately.