<noframes id="zd9f3">

    <address id="zd9f3"></address>

    <address id="zd9f3"></address>
    <address id="zd9f3"></address>

    <address id="zd9f3"><nobr id="zd9f3"><meter id="zd9f3"></meter></nobr></address>
    1. Protein Tyrosine Kinase/RTK
    2. Pyk2

    Pyk2

    Proline-rich tyrosine kinase 2 (Pyk2) is a cytoplasmic, non-receptor tyrosine kinase implicated in multiple signaling pathways. It is a negative regulator of osteogenesis and considered a viable drug target for osteoporosis treatment.

    Pyk2 and focal adhesion kinase (FAK) comprise the focal adhesion kinase subfamily of non-receptor tyrosine kinases. PYK2 and FAK are large multidomain proteins containing an N-terminal FERM domain, a central catalytic domain, and a C-terminal segment containing dual proline rich (PR) subdomains and a focal adhesion targeting (FAT) region.

    Pyk2, a non-receptor tyrosine kinase of the FAK family, is up-regulated in more than 60% of the tumors of hepatocellular carcinoma (HCC) patients.

    Pyk2 相关产品 (4):

    Cat. No. Product Name Effect Purity
    • HY-10459
      PF-562271 Inhibitor 99.36%
      PF-562271 是有效,可逆,ATP竞争性的 FAKPyk2 激酶抑制剂,IC50 分别为 1.5 和 13 nM。
    • HY-10460
      PF-431396 Inhibitor 99.15%
      PF-431396 is dual focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2) inhibitor (IC50 values are 2 and 11 nM respectively), PF-431396 has a Kd value of 445 nM for BRD4.
    • HY-13203
      NVP-TAE 226 Inhibitor 98.98%
      NVP-TAE 226 是一种双重酪氨酸激酶抑制剂,作用于 FAKIGF-IRIC50 分别为 5.5 nM 和 0.14 μM。
    • HY-10458
      PF-562271 besylate Inhibitor 98.31%
      PF-562271 besylate 是有效,可逆,ATP竞争性的 FAKPyk2 激酶抑制剂,IC50 分别为 1.5 和 13 nM。
    Isoform Specific Products

    Your Search Returned No Results.

    Sorry. There is currently no product that acts on isoform together.

    Please try each isoform separately.

    台山壳琳装饰材料公司