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    1. Immunology/Inflammation
    2. SPHK


    SphK (sphingosine kinase) is the major source of the bioactive lipid and GPCR (G-protein-coupled receptor) agonist S1P (sphingosine 1-phosphate). S1P promotes cell growth, survival and migration, and is a key regulator of lymphocyte trafficking. Inhibition of S1P signalling has been proposed as a strategy for treatment of inflammatory diseases and cancer.

    S1P is an extracellular ligand at five cognate GPCRs, S1PRs and a consequential intracellular lipid intermediate that affects diverse cellular processes including migration, growth and survival. S1P regulates function and trafficking of immune cells, induces angiogenesis and regulates endothelial cell functions, promotes survival and migration of cancer cells, and has been implicated as an important mediator in the pathogenesis of cancer and autoimmune and allergic diseases.

    SPHK 相关产品 (9):

    Cat. No. Product Name Effect Purity
    • HY-16015
      Opaganib Inhibitor 99.68%
      Opaganib (ABC294640) 是一种选择性的竞争性的鞘氨醇激酶 2 (SK2) 抑制剂,Ki 为 9.8 μM。
    • HY-15779A
      K145 hydrochloride Inhibitor 99.96%
      K145盐酸盐是SphK2选择性抑制剂,IC50为4.3μM,在10 μM浓度时对SphK1无抑制性。
    • HY-101805
      SK1-IN-1 Inhibitor >98.0%
      SK1-IN-1是一种有效的鞘氨醇激酶1 (SPHK1) 抑制剂,IC50 值为58 nM。
    • HY-15425A
      PF-543 Citrate Inhibitor 98.22%
      PF-543 Citrate是新颖的可渗透细胞的SPHK1抑制剂,Ki值为4.3 nM。对SPHK1的选择性是SPHK2的100倍以上。
    • HY-13822
      SKI II Inhibitor 99.98%
      SKI II是一种合成的鞘氨醇激酶 (SK) 抑制剂, 抑制SK1和SK2, IC50值分别为78 μM和45 μM。
    • HY-101572
      MHP Activator 98.02%
      MHP 是 SPHK1 的激活剂,能够刺激 KC细胞中 CAMP mRNA 的表达和蛋白的产生。
    • HY-19794
      MP-A08 Inhibitor >98.0%
    • HY-15425
      PF-543 Inhibitor
      PF-543是新颖的可渗透细胞的SPHK1抑制剂,Ki值为4.3 nM。对SPHK1的选择性是SPHK2的100倍以上。
    • HY-15779
      K145 Inhibitor
      K145是SphK2选择性抑制剂,IC50为4.3μM,在10 μM浓度时对SphK1无抑制性。
    Isoform Specific Products

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    Please try each isoform separately.