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    1. Immunology/Inflammation
    2. STING


    STING (Stimulator of Interferon Genes) is a transmembrane protein localized to the endoplasmic reticulum that undergoes a conformational change in response to direct binding of cyclic dinucleotides (CDNs), resulting in a downstream signaling cascade involving TBK1 activation, IRF-3 phosphorylation, and production of IFN-β and other cytokines.

    STING is a pattern recognition receptor of cyclic dinucleotides as well as an innate immune adaptor protein that enables signaling from cytoplasmic receptors to the transcription factor interferon regulatory factor 3. Initiation of these pathways leads to the expression of type I interferons and proteins associated with antiviral and antitumor immunity. Small molecules capable of triggering STING-dependent cellular processes are effective at blocking virus replication, enhancing vaccine efficacy, and facilitating immune response to cancer cells.

    STING 相关产品 (14):

    Cat. No. Product Name Effect Purity
    • HY-100941
      CCCP Inhibitor 99.83%
    • HY-12885B
      ADU-S100 ammonium salt Activator 99.23%
      ADU-S100 ammonium salt (ML RR-S2 CDA ammonium salt; MIW815 ammonium salt) 是干扰素基因刺激物的激活剂 (STING)。
    • HY-10964
      Vadimezan Agonist 99.81%
      Vadimezan (ASA-404; DMXAA) 是血管破坏剂,是鼠干扰素基因 (STING) 刺激物,也是I型IFN和其他细胞因子的强效诱导剂。
    • HY-112906
      C-176 Inhibitor >98.0%
      C-176 是干扰素基因刺激受体 (STING) 的强效共价抑制剂。
    • HY-12885
      ADU-S100 Activator 99.23%
      ADU-S100 (ML RR-S2 CDA; MIW815) 是干扰素基因刺激物的激活剂 (STING)。
    • HY-112921B
      diABZI STING agonist-1 trihydrochloride Agonist 99.89%
      diABZI STING agonist-1 (trihydrochloride) 是一个选择性的干扰素基因刺激受体 (STING) 的激动剂。
    • HY-112921
      diABZI STING agonist-1 Tautomerism Agonist
      diABZI STING agonist-1 (Tautomerism) 是一个选择性的干扰素基因刺激受体 (STING) 的激动剂,其在人中的 EC50 值为 130 nM。
    • HY-19711
      STING agonist-1 Agonist 99.06%
      STING agonist-1 (G10) 是一种新型人类特异性的STING激动剂, 针对新出现的甲病毒, 可引发抗病毒活性, G10有效抑制甲病毒属委内瑞拉马脑脊髓炎病毒 (VEEV) 复制 (IC90=24.57 μM)。
    • HY-107780
      Cyclic-di-GMP Agonist 99.26%
      Cyclic-di-GMP 是 STING 的激动剂也是一个可以调节不同细菌物种的生物膜形成,运动性和毒力的第二信使。
    • HY-12512
      cGAMP Activator 98.56%
      cGAMP(Cyclic GMP-AMP)是多细胞动物内源性第二信使,能激发干扰素的产生,STING配体和活化剂。
    • HY-112921A
      diABZI STING agonist-1 Agonist
      diABZI STING agonist-1 是一个选择性的干扰素基因刺激受体 (STING) 的激动剂。
    • HY-112878
      CL656 Activator
      CL656是干扰素基因刺激因子 (STING) 的激活剂。
    • HY-114399
      STING ligand-1
      STING ligand-1 是一种 STING 配体,作用于 HAQ STING 的 IC50 为 68 nM。
    • HY-112951
      ChX710可以启动 I 型干扰素对胞质 DNA 的反应,诱导 ISRE 启动子序列、特异性细胞干扰素刺激基因 (ISGs) 和干扰素调节因子(IRF) 3的磷酸化。
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